KEGG   ENZYME: 1.4.1.20Help
Entry
EC 1.4.1.20                 Enzyme                                 
Name
phenylalanine dehydrogenase;
L-phenylalanine dehydrogenase;
PHD
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH + H+ [RN:R00688]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
phenylpyruvate [CPD:C00166];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine.
Pathway
Tyrosine metabolism
Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00270  
phenylalanine dehydrogenase
Genes
BHA: 
BH0218(pdh)
OIH: 
GKA: 
GK2031(pdh)
GTN: 
GTH: 
GYC: 
GYA: 
GMC: 
ESI: 
Taxonomy
Reference
1  [PMID:3112142]
  Authors
Asano Y, Nakazawa A, Endo K.
  Title
Novel phenylalanine dehydrogenases from Sporosarcina ureae and Bacillus sphaericus. Purification and characterization.
  Journal
J. Biol. Chem. 262 (1987) 10346-54.
  Organism
Sporosarcina ureae, Bacillus sphaericus
Reference
2  [PMID:3311741]
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K.
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur. J. Biochem. 168 (1987) 153-9.
  Organism
Bacillus badius
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
69403-12-9
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