| Entry |
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| Name |
aspartate dehydrogenase;
NAD-dependent aspartate dehydrogenase;
NADH2-dependent aspartate dehydrogenase;
NADP+-dependent aspartate dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-aspartate:NAD(P)+ oxidoreductase (deaminating)
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| Reaction(IUBMB) |
L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+ [RN: R07164 R07165]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme is strictly specific for L-aspartate as substrate. Catalyses the first step in NAD biosynthesis from aspartate. The enzyme has a higher affinity for NAD+ than NADP+ [1].
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| Pathway |
| Nicotinate and nicotinamide metabolism | | Metabolic pathways |
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| Orthology |
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| Genes |
EBT: | | ENC: | | ENO: | | ECLO: | | EEC: | | ENL: | | EAE: | | EAR: | | KPN: | | KPM: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PSI: | | ROR: | | EBF: | | FAU: | | PAE: | | PFC: | | PCR: | | ACI: | | ACD: | | ACB: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | PHA: | | TTU: | | CSA: | | RSO: | | RSL: | | RSN: | | RPI: | | RPF: | | REU: | | REH: | | CTI: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BTE: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BUG: | | BGF: | | BGD: | | BYI: | | BPX: | | BPE: | | BPC: | | BPER: | | BPA: | | BPAR: | | BBR: | | BBM: | | BBH: | | BAV: | | AXY: | | PUT: | | AKA: | | POL: | | DAC: | | DEL: | | VAP: | | VPE: | | CTT: | | HSE: | | MES: | | AVI: | | OAN: | | BJA: | | BJU: | | BRS: | | RPB: | | AZC: | | CAK: | | SIL: | | SIT: | | JAN: | | RDE: | | RLI: | | PDE: | | DSH: | | KVU: | | KVL: | | PSF: | | OAR: | | PGV: | | SIV: | | CPY: | | CSH: | | FAA: | | RHO: | | FPA: | | ERH: | | CGT: | | CAR: | | SALB: | | AAU: | | AAI: | | ARR: | | RSA: | | TPI: | | BVU: | | BXY: | | PSN: | | CAO: | | FBA: | | STI: | | TMA: | | TPT: | | TRQ: | | TNA: | | TNP: | | TTA: | | TME: | | TAF: | | FPE: | | MPZ: | | MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MAE: | | MVN: | | MVO: | | MOK: | | MAC: | | MBA: | | MMA: | | MMAZ: | | MBU: | | MMH: | | MEV: | | MZH: | | MPY: | | MHZ: | | MCJ: | | MHI: | | MHU: | | MLA: | | MEM: | | MBG: | | MPI: | | MBN: | | MFO: | | MPL: | | MPD: | | MEZ: | | RCI: | | MTH: | | MMG: | | MST: | | MSI: | | MRU: | | MEL: | | MEW: | | MFV: | | MKA: | | AFU: | | AVE: | | FPL: | | TAR: | | ABI: | | ACF: | | MAX: | | IHO: | | HBU: | | PFM: | | PYR: | | NMR: | | NIR: | | NKR: | | CSY: | | NGA: | | HAH: | |
» show all
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| Reference |
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| Authors |
Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L. |
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| Title |
Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. |
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| Journal |
J. Biol. Chem. 278 (2003) 8804-8. |
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| Organism |
Thermotoga maritima [GN: tma] |
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| Reference |
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| Authors |
Okamura T, Noda H, Fukuda S, Ohsugi M. |
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| Title |
Aspartate dehydrogenase in vitamin B12-producing Klebsiella pneumoniae IFO 13541. |
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| Journal |
J. Nutr. Sci. Vitaminol. (Tokyo). 44 (1998) 483-90. |
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| Organism |
Klebsiella pneumoniae |
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| Reference |
3 |
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| Authors |
Kretovich, W.L., Kariakina, T.I., Weinova, M.K., Sidelnikova, L.I. and Kazakova, O.W. |
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| Title |
The synthesis of aspartic acid in Rhizobium lupini bacteroids. |
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| Journal |
Plant Soil 61 (1981) 145-156. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37278-97-0 |
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