KEGG   ENZYME: 1.4.1.23Help
Entry
EC 1.4.1.23                 Enzyme                                 

Name
valine dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-valine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+ [RN:R01434]
Reaction(KEGG)
Substrate
L-valine [CPD:C00183];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
3-methyl-2-oxobutanoate [CPD:C00141];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].
History
EC 1.4.1.23 created 2012
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00271  
valine dehydrogenase (NAD+)
Genes
ASD: 
NCY: 
RHA: 
RER: 
REY: 
ROP: 
ROA: 
RPY: 
SCO: 
SCO4089(SCD25.25c)
SMA: 
SGR: 
SCB: 
SSX: 
SVL: 
SCT: 
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SLV: 
KSK: 
NCA: 
TCU: 
SRO: 
FRA: 
FRE: 
FRI: 
FAL: 
FSY: 
GOB: 
BSD: 
MMAR: 
SVI: 
TBI: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AMQ: 
AMETH_5418(gdhA1)
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
AMS: 
ASE: 
ACTN: 
AFS: 
CAI: 
SNA: 
 » show all
Taxonomy
Reference
1  [PMID:3182727]
  Authors
Vancurova I, Vancura A, Volc J, Neuzil J, Flieger M, Basarova G, Behal V.
  Title
Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens.
  Journal
J. Bacteriol. 170 (1988) 5192-6.
Reference
2  [PMID:2324704]
  Authors
Navarrete RM, Vara JA, Hutchinson CR
  Title
Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2).
  Journal
J. Gen. Microbiol. 136 (1990) 273-81.
  Sequence
[sco:SCO4089]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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