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Entry
EC 1.4.1.24                 Enzyme                                 

Name
3-dehydroquinate synthase II;
DHQ synthase II;
MJ1249 (gene name);
aroB' (gene name)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+ [RN:R08569]
Reaction(KEGG)
Substrate
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
3-dehydroquinate [CPD:C00944];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.
History
EC 1.4.1.24 created 2012
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Biosynthesis of secondary metabolites
Orthology
K11646  
3-dehydroquinate synthase II
Genes
DEL: 
DVM: 
DVG: 
DDE: 
DDS: 
DDN: 
DMA: 
DSA: 
DAS: 
DAF: 
DHY: 
DPI: 
DGG: 
DBA: 
DRT: 
SUR: 
DAO: 
AXL: 
HHD: 
AAE: 
HHO: 
HYS: 
HTH: 
HTE: 
TAL: 
TRD: 
SAF: 
PMX: 
TAM: 
DTE: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MMA: 
MMAZ: 
MBU: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_1239(aroB)
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
Mtc_1382(aroB)
RCI: 
RRC152(aroB)
MER: 
MTH: 
MMG: 
MST: 
MSI: 
MRU: 
mru_0998(aroB)
MEB: 
Abm4_0655(aroB)
MEL: 
MEW: 
METH: 
MFV: 
MKA: 
MAX: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
HAL: 
HSL: 
HMA: 
rrnAC1879(aroB)
HHI: 
HAH_2395(aroB)
HHN: 
HWA: 
HQ1155A(aroB)
HWC: 
Hqrw_1192(aroB)
NPH: 
NMO: 
Nmlp_1201(aroB)
HLA: 
HUT: 
HTI: 
HMU: 
HTU: 
NMG: 
HVO: 
HME: 
HJE: 
HBO: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
TAR: 
NMR: 
NIR: 
NKR: 
CSY: 
NGA: 
NVN: 
NEV: 
CSU: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:15182204]
  Authors
White RH.
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry. 43 (2004) 7618-27.
  Sequence
[mja:MJ_1249]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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