KEGG ENZYME: 1.4.1.9

KEGG

ENZYME: 1.4.1.9

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Entry

EC 1.4.1.9 Enzyme

Name

leucine dehydrogenase;
L-leucine dehydrogenase;
L-leucine:NAD+ oxidoreductase, deaminating;
LeuDH

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor

BRITE hierarchy

Sysname

L-leucine:NAD+ oxidoreductase (deaminating)

Reaction(IUBMB)

L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+ [RN:R01088]

Reaction(KEGG)

R01088;
(other) R00145 R00146 R01434 R02196 R03960

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Substrate

L-leucine [CPD:C00123];
H2O [CPD:C00001];
NAD+ [CPD:C00003]

Product

4-methyl-2-oxopentanoate [CPD:C00233];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also acts on isoleucine, valine, norvaline and norleucine.

Pathway

ec00280	Valine, leucine and isoleucine degradation
ec00290	Valine, leucine and isoleucine biosynthesis
ec01100	Metabolic pathways
ec01110	Biosynthesis of secondary metabolites

Orthology

leucine dehydrogenase

Genes

XCC:	XCC1299(leu)
XCB:	XC_2941
XCA:	xccb100_3003
XCV:	XCV1403(ldh)
XCP:	XCR_1557
XAC:	XAC1350(leu)
XAX:	XACM_1334(leu)
XAO:	XAC29_06810
XOO:	XOO1883(leu)
XOM:	XOO_1780
XOP:	PXO_01746
XOR:	XOC_3153
XAL:	XALc_2523
XCI:	XCAW_02996(gdhA)
SML:	Smlt3523(vdh)
SMT:	Smal_2953
BUJ:	BurJV3_2983
SMZ:	SMD_3104(vdh)
PSU:	Psesu_1633
PSD:	DSC_09715
RHD:	R2APBS1_2559
PAE:	PA3418(ldh)
PAU:	PA14_19870(ldh)
PAP:	PSPA7_1708(ldh)
PAG:	PLES_16421(ldh)
PAF:	PAM18_1547(ldh)
PNC:	NCGM2_4556(ldh)
PDK:	PADK2_07170
PSG:	G655_07625
PPU:	PP_4617
PPF:	Pput_4477
PPG:	PputGB1_4601
PPW:	PputW619_0821
PPT:	PPS_4442
PPB:	PPUBIRD1_4312
PPI:	YSA_03174
PPX:	T1E_1560(leudh)
PPUH:	B479_22345
PPUU:	PputUW4_00829
PFL:	PFL_0973(ldh)
PFO:	Pfl01_0915
PFS:	PFLU1030
PFE:	PSF113_4858
PFC:	PflA506_1009(ldh)
PPZ:	H045_01865
PEN:	PSEEN4606
PMY:	Pmen_2875 Pmen_3248
PMK:	MDS_1783 MDS_3545
PSA:	PST_0867(ldh)
PSZ:	PSTAB_0759
PSR:	PSTAA_0810(ldh)
PSC:	A458_17470
PSJ:	PSJM300_16285
PSH:	Psest_3516
PBA:	PSEBR_a4692
PDR:	H681_19860
AVN:	Avin_10760
AVL:	AvCA_10760
AVD:	AvCA6_10760
SON:	SO_2638(ldh)
SDN:	Sden_1823
SFR:	Sfri_2265
SAZ:	Sama_2067
SBL:	Sbal_2483
SBM:	Shew185_2476
SBN:	Sbal195_2596
SBP:	Sbal223_1868
SBT:	Sbal678_2599
SBS:	Sbal117_2619
SBB:	Sbal175_1895
SLO:	Shew_1555
SPC:	Sputcn32_2238
SHP:	Sput200_2261
SSE:	Ssed_1877
SPL:	Spea_2543
SHE:	Shewmr4_1598
SHM:	Shewmr7_1673
SHN:	Shewana3_1742
SHW:	Sputw3181_1771
SHL:	Shal_1711
SWD:	Swoo_2710
SWP:	swp_1857
SVO:	SVI_1816(ldh)
ILO:	IL1314
CPS:	CPS_2904
PHA:	PSHAa1167(bcd)
PAT:	Patl_2995
PSM:	PSM_A1857(bcd)
MAQ:	Maqu_2878
MHC:	MARHY2772(leuDH)
MAD:	HP15_2623(ldh)
MBS:	MRBBS_3059(ldh)
AMC:	MADE_1006200
AMAC:	MASE_05160
AMB:	AMBAS45_05390
AMG:	AMEC673_05245
AMK:	AMBLS11_05270
AMAA:	amad1_05575
ALT:	ambt_12985
GAG:	Glaag_1333
GNI:	GNIT_2308
GPS:	C427_3613
FBL:	Fbal_2000
CBU:	CBU_0641
CBS:	COXBURSA331_A0755
CBD:	CBUD_0652
CBG:	CbuG_1363
CBC:	CbuK_1615
LPN:	lpg2276
LPU:	LPE509_00814
LPF:	lpl2202
LPP:	lpp2230
LPC:	LPC_1745
LPA:	lpa_03275(gdhA)
LPE:	lp12_2268
LLO:	LLO_0604
NOC:	Noc_1436
NHL:	Nhal_1214
HCH:	HCH_00319
HEL:	HELO_2552
ADI:	B5T_01835
KKO:	Kkor_1133
SAGA:	M5M_18625
PSE:	NH8B_2063
REU:	Reut_B5816 Reut_C6219
REH:	H16_B0449
CNC:	CNE_2c04000(ldh)
BXE:	Bxe_A2689
BPH:	Bphy_3953
BYI:	BYI23_C001260
CFU:	CFU_0193(bcd)
AZA:	AZKH_3648
TMZ:	Tmz1t_1037
BBA:	Bd2028
BBAT:	Bdt_1997
BEX:	A11Q_1315
BMX:	BMS_3181(ldh)
MXA:	MXAN_1074
MFU:	LILAB_03265
MSD:	MYSTI_01116
SCL:	sce6206
HOH:	Hoch_4303
MES:	Meso_3241
CCR:	CC_2082
CCS:	CCNA_02164
CAK:	Caul_3328
CSE:	Cseg_1345
PZU:	PHZ_c0894
AEX:	Astex_2035
SIL:	SPO0390
SIT:	TM1040_2779
PDE:	Pden_4625
PSF:	PSE_4814(pdh)
PGA:	PGA1_c20500(ldh)
PGL:	PGA2_c19340(ldh)
MMR:	Mmar10_0963
HNE:	HNE_1615(ldh1) HNE_2735(ldh2)
HBA:	Hbal_2132
NPP:	PP1Y_Mpl2025
SAL:	Sala_1521 Sala_1973
SWI:	Swit_3986
SPHM:	G432_00795
SSY:	SLG_13460
ELI:	ELI_03850
RRU:	Rru_A1040
RRF:	F11_05355
RCE:	RC1_1776
ABS:	AZOBR_p470040(ldh)
TMO:	TMO_2570
MAI:	MICA_607
MAN:	A11S_530
APC:	HIMB59_00001080
BSU:	BSU24080(bcd)
BSR:	I33_2486
BSL:	A7A1_3635
BSH:	BSU6051_24080(bcd)
BSY:	I653_11550
BSS:	BSUW23_11905(bcd)
BST:	GYO_2653
BSO:	BSNT_03584(bcd)
BSN:	BSn5_02575
BSQ:	B657_24080(bcd)
BSUB:	BEST7613_3962(bcd)
BSX:	C663_2289(bcd)
BLI:	BL01501(bcd)
BLD:	BLi02585(bcd)
BAO:	BAMF_2305(bcd)
BAY:	RBAM_022360(bcd)
BAQ:	BACAU_2249(bcd)
BYA:	BANAU_2388(bcd)
BAMP:	B938_11555
BAML:	BAM5036_2159(bcd)
BAZ:	BAMTA208_12345(bcd)
BQL:	LL3_02594(bcd)
BXH:	BAXH7_02517(bcd)
BQY:	MUS_2698(bcd)
BAMI:	KSO_008215
BAE:	BATR1942_10345
BHA:	BH2765
BAN:	BA_4387
BAR:	GBAA_4387
BAT:	BAS4070
BAH:	BAMEG_4424
BAI:	BAA_4406
BAX:	H9401_4183
BAL:	BACI_c41310(dhlE)
BCE:	BC4162
BCA:	BCE_4237
BCZ:	BCZK3917(dhlE)
BCR:	BCAH187_A4295
BCB:	BCB4264_A4275
BCU:	BCAH820_4185
BCG:	BCG9842_B0959
BCQ:	BCQ_3952(dhlE)
BCX:	BCA_4274
BNC:	BCN_4078
BCF:	bcf_20700
BCER:	BCK_14355
BCY:	Bcer98_2859
BTK:	BT9727_3908(dhlE)
BTL:	BALH_3775(dhlE)
BTB:	BMB171_C3825
BTT:	HD73_4467
BTC:	CT43_CH4178
BTF:	YBT020_20520
BTM:	MC28_3456(sodA1)
BTG:	BTB_c43060(ldh1)
BTI:	BTG_28575
BTN:	BTF1_19150
BTHT:	H175_ch4247
BWE:	BcerKBAB4_4006
BCL:	ABC2453(bcd)
BPU:	BPUM_2147(bcd)
BPF:	BpOF4_01430
BMQ:	BMQ_4442(bcd)
BMD:	BMD_4428(bcd)
BMH:	BMWSH_0793(bcd)
BSE:	Bsel_2256
BCO:	Bcell_1731
BCK:	BCO26_1641
BAG:	Bcoa_2873
BJS:	MY9_2426
OIH:	OB1869
GKA:	GK2381
GTN:	GTNG_2310
GTH:	Geoth_1305
GTE:	GTCCBUS3UF5_26720
GWC:	GWCH70_2308
GYC:	GYMC61_0262
GYA:	GYMC52_2403
GCT:	GC56T3_1109
GMC:	GY4MC1_1196
GGH:	GHH_c24540(bcd)
AFL:	Aflv_0959(bcd)
SSD:	SPSINT_2096
SDT:	SPSE_0360(dhlE)
SWA:	A284_11065
LSP:	Bsph_3496
HHD:	HBHAL_3459(ldh)
ESI:	Exig_0916
EAT:	EAT1b_0510
EAN:	Eab7_0886
MCL:	MCCL_1161
BBE:	BBR47_23670(ldh)
PJD:	Pjdr2_5970
PMS:	KNP414_05663
PMQ:	PM3016_5007
PMW:	B2K_25965
AAC:	Aaci_1459
AAD:	TC41_1398
BTS:	Btus_1308
SIV:	SSIL_1713
STH:	STH1827 STH1830
DOR:	Desor_1054
DAI:	Desaci_3322 Desaci_4535
ELM:	ELI_3459
TMR:	Tmar_1151 Tmar_1152
SAY:	TPY_1073 TPY_3272
SAP:	Sulac_1639 Sulac_2575
TTE:	TTE2202(GdhA3) TTE2203(GdhA4)
TEX:	Teth514_0938
THX:	Thet_1979
TPD:	Teth39_0461
TIT:	Thit_1917
TMT:	Tmath_1879
TBO:	Thebr_0473
TWI:	Thewi_2187
CHY:	CHY_0579(ldh)
TPZ:	Tph_c04750(ldh)
TOC:	Toce_0831 Toce_1567
TXY:	Thexy_1634
TSH:	Tsac_2182
NTH:	Nther_1681 Nther_2349
HOR:	Hore_06730 Hore_06750
HPK:	Hprae_1352
CHN:	A605_13830
RER:	RER_59820(pdh)
GBR:	Gbro_4113
GPO:	GPOL_c45190
SVL:	Strvi_3361
SDV:	BN159_0132
MTS:	MTES_2824
BCV:	Bcav_4087
KSE:	Ksed_04400
VMA:	VAB18032_12700
CAI:	Caci_4348
RXY:	Rxyl_2467
CWO:	Cwoe_1545 Cwoe_2247 Cwoe_4384 Cwoe_4404
CTR:	CT773(ldh)
CTRD:	SOTOND1_00828
CTRO:	SOTOND5_00826
CTRT:	SOTOND6_00826
CTA:	CTA_0843(ldh)
CTY:	CTR_7771(ldh)
CTRQ:	A363_00835
CTRX:	A5291_00834
CTRZ:	A7249_00833
CTRP:	L11322_00822
CTLJ:	L1115_00822
CTLX:	L1224_00822
CTLL:	L1440_00825
CTB:	CTL0142(ldh)
CTRR:	L225667R_00823
CTLF:	CTLFINAL_00765
CTLI:	CTLINITIAL_00765
CTL:	CTLon_0142(ldh)
CTRU:	L2BUCH2_00821
CTRL:	L2BLST_00821
CTRV:	L2BCV204_00821
CTRM:	L2BAMS1_00821
CTLA:	L2BAMS2_00821
CTLM:	L2BAMS3_00821
CTLS:	L2BAMS4_00821
CTLZ:	L2BAMS5_00822
CTLC:	L2BCAN1_00823
CTLN:	L2BCAN2_00820
CTLB:	L2B795_00821
CTLQ:	L2B8200_00821
CTO:	CTL2C_412
CTRN:	L3404_00821
CTJ:	JALI_7781(ldh)
CTZ:	CTB_7781(ldh)
CTG:	E11023_04090
CTK:	E150_04125
CSW:	SW2_7851(ldh)
CES:	ESW3_7851(ldh)
CTRB:	BOUR_00830
CTRE:	SOTONE4_00825
CTRS:	SOTONE8_00832
CFS:	FSW4_7851(ldh)
CFW:	FSW5_7851(ldh)
CTRF:	SOTONF3_00826
CTN:	G11074_04090
CTQ:	G11222_04120
CTV:	CTG9301_04105
CTW:	G9768_04095
CTRG:	SOTONG1_00827
CTRI:	BN197_7831(ldh)
CTRA:	BN442_7831(ldh)
CTRH:	SOTONIA1_00829
CTRJ:	SOTONIA3_00829
CTRK:	SOTONK1_00826
CMU:	TC0154
CPN:	CPn0919(ldh)
CPA:	CP0947
CPJ:	CPj0919(ldh)
CPT:	CpB0951
CLP:	CPK_ORF00331(ldh)
CPM:	G5S_0113
CHP:	CPSIT_0896
CHB:	G5O_0887
CHS:	CPS0A_0916
CHI:	CPS0B_0902
CHT:	CPS0D_0912
CHC:	CPS0C_0914
CHR:	Cpsi_8311
CPSC:	B711_0964(ldh)
CPSN:	B712_0905(ldh)
CPSB:	B595_0966
CPSG:	B598_0901(ldh)
CPSM:	B602_0905(ldh)
CPSI:	B599_0901(ldh)
CPSV:	B600_0962(ldh)
CPSW:	B603_0907(ldh)
CPST:	B601_0904(ldh)
CPSD:	BN356_8341
CPSA:	AO9_04360
CCA:	CCA00850
CAB:	CAB815
CFE:	CF0166(gdhA)
PUV:	PUV_27590(ldh)
WCH:	wcw_1707(gdhA)
SNG:	SNE_A05300(ldh-A) SNE_A22050(ldh-B)
BPO:	BP951000_1669
BPJ:	B2904_orf2247
BPIP:	BPP43_06875
BPW:	WESB_0502
BIP:	Bint_2325
PHE:	Phep_1400
PSN:	Pedsa_2085
SHG:	Sph21_4008
SCN:	Solca_2343
CMR:	Cycma_2079
BBD:	Belba_0522
EVI:	Echvi_1756
FLI:	Fleli_1154
MTT:	Ftrac_1913
GFO:	GFO_2528(ldh)
FJO:	Fjoh_2201
FPS:	FP0533(vdh)
FCO:	FCOL_00595
FIN:	KQS_03905(vdh)
ZPR:	ZPR_0855
CAT:	CA2559_12928
LAN:	Lacal_1929
ASL:	Aeqsu_0321
NDO:	DDD_0408
FTE:	Fluta_3435
OHO:	Oweho_0867
AAS:	Aasi_0423
CHE:	CAHE_0638(ldh)
IPO:	Ilyop_0980
GAU:	GAU_1293
AMO:	Anamo_0104
SYW:	SYNW0232
SYD:	Syncc9605_0225
SYE:	Syncc9902_0253
SYG:	sync_0270
SYR:	SynRCC307_2295
SYX:	SynWH7803_0275
CYC:	PCC7424_2278
CYJ:	Cyan7822_2405
ANA:	all0426
NPU:	Npun_R1275
NOP:	Nos7524_0908
RIV:	Riv7116_1899
PMC:	P9515_04091
PMH:	P9215_04071
CTHE:	Chro_3118
DRA:	DR_0158
DGE:	Dgeo_0203
DDR:	Deide_00380
DMR:	Deima_0460
DPT:	Deipr_1859
DGO:	DGo_CA2729
DPD:	Deipe_0837
NMG:	Nmag_2994
NGE:	Natgr_3353
HRU:	Halru_2629
NOU:	Natoc_1558

Taxonomy

Reference

1 [PMID:13746411]

Authors

SANWAL BD, ZINK MW.

Title

L-Leucine dehydrogenase of Bacillus cereus.

Journal

Arch. Biochem. Biophys. 94 (1961) 430-5.

Organism

Bacillus cereus

Reference

2

Authors

Zink, M.W. and Sanwal, B.D.

Title

The distribution and substrate specificity of L-leucine dehydrogenase.

Journal

Arch. Biochem. Biophys. 99 (1962) 72-77.

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:

9082-71-7

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical substance (17)   
   KEGG COMPOUND (17)   
Chemical reaction (27)   
   KEGG REACTION (6)   
   KEGG RPAIR (17)   
   KEGG RCLASS (4)   
Gene (516)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (468)   
   KEGG EGENES (3)   
   KEGG MGENES (44)   
Protein sequence (1111)   
   UniProt (540)   
   PRF (23)   
   RefSeq(pep) (542)   
   PDBSTR (4)   
   PMD (2)   
DNA sequence (867)   
   RefSeq(nuc) (499)   
   GenBank (184)   
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3D Structure (2)   
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Protein domain (1)   
   PROSITE(DOC) (1)   
Literature (1)   
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Enzyme (4)   
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