KEGG   ENZYME: 1.4.3.14Help
Entry
EC 1.4.3.14                 Enzyme                                 

Name
L-lysine oxidase;
L-lysine alpha-oxidase;
L-lysyl-alpha-oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
L-lysine:oxygen 2-oxidoreductase (deaminating)
Reaction(IUBMB)
L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2 [RN:R00447]
Reaction(KEGG)
Substrate
L-lysine [CPD:C00047];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
6-amino-2-oxohexanoate [CPD:C03239];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
Also acts, more slowly, on L-ornithine, L-phenylalanine, L-arginine and L-histidine.
History
EC 1.4.3.14 created 1981
Pathway
Lysine degradation
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Reference
1  [PMID:6101334]
  Authors
Kusakabe H, Kodama K, Kuninaka A, Yoshino H, Misono H, Soda K.
  Title
A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties.
  Journal
J. Biol. Chem. 255 (1980) 976-81.
  Organism
Trichoderma viride
Reference
2  [PMID:12460113]
  Authors
Lukasheva EV, Berezov TT.
  Title
L-Lysine alpha-oxidase: physicochemical and biological properties.
  Journal
Biochemistry. (Mosc). 67 (2002) 1152-8.
  Organism
Trichoderma viride
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
70132-14-8

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