KEGG   ENZYME: 1.4.3.24Help
Entry
EC 1.4.3.24                 Enzyme                                 

Name
pseudooxynicotine oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-(methylamino)-1-(pyridin-3-yl)butan-1-one:oxygen oxidoreductase (methylamine releasing)
Reaction(IUBMB)
4-(methylamino)-1-(pyridin-3-yl)butan-1-one + H2O + O2 = 4-oxo-4-(pyridin-3-yl)butanal + methylamine + H2O2 [RN:R10103]
Reaction(KEGG)
Substrate
4-(methylamino)-1-(pyridin-3-yl)butan-1-one [CPD:C20361];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
4-oxo-4-(pyridin-3-yl)butanal [CPD:C19567];
methylamine [CPD:C00218];
H2O2 [CPD:C00027]
Comment
Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacterium Pseudomonas sp. HZN6, is involved the nicotine degradation.
History
EC 1.4.3.24 created 2012
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K20158  
pseudooxynicotine oxidase
Genes
PPT: 
PMON: 
PMOT: 
Taxonomy
Reference
1  [PMID:22267672]
  Authors
Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W
  Title
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.
  Journal
Appl. Environ. Microbiol. 78 (2012) 2154-60.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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