KEGG   ENZYME: 1.4.9.2Help
Entry
EC 1.4.9.2                  Enzyme                                 

Name
aralkylamine dehydrogenase (azurin);
aromatic amine dehydrogenase;
arylamine dehydrogenase;
tyramine dehydrogenase;
aralkylamine:(acceptor) oxidoreductase (deaminating)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With a copper protein as acceptor
BRITE hierarchy
Sysname
aralkylamine:azurin oxidoreductase (deaminating)
Reaction(IUBMB)
ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin
Reaction(KEGG)
Substrate
ArCH2NH2;
H2O [CPD:C00001];
azurin
Product
ArCHO;
NH3 [CPD:C00014];
reduced azurin [CPD:C05358]
Comment
Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine
History
EC 1.4.9.2 created 1986 as EC 1.4.99.4, transferred 2011 to 1.4.9.2
Pathway
Tyrosine metabolism
Phenylalanine metabolism
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13371  
aralkylamine dehydrogenase light chain
K13372  
aralkylamine dehydrogenase heavy chain
Reference
1  [PMID:6830237]
  Authors
Iwaki M, Yagi T, Horiike K, Saeki Y, Ushijima T, Nozaki M.
  Title
Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp.
  Journal
Arch. Biochem. Biophys. 220 (1983) 253-62.
Reference
2  [PMID:7547967]
  Authors
Hyun YL, Davidson VL
  Title
Electron transfer reactions between aromatic amine dehydrogenase and azurin.
  Journal
Biochemistry. 34 (1995) 12249-54.
Reference
3  [PMID:10506161]
  Authors
Hyun YL, Zhu Z, Davidson VL
  Title
Gated and ungated electron transfer reactions from aromatic amine dehydrogenase to azurin.
  Journal
J. Biol. Chem. 274 (1999) 29081-6.
Reference
4  [PMID:15234267]
  Authors
Davidson VL
  Title
Electron transfer in quinoproteins.
  Journal
Arch. Biochem. Biophys. 428 (2004) 32-40.
Reference
5  [PMID:17087503]
  Authors
Sukumar N, Chen ZW, Ferrari D, Merli A, Rossi GL, Bellamy HD, Chistoserdov A, Davidson VL, Mathews FS
  Title
Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis.
  Journal
Biochemistry. 45 (2006) 13500-10.
  Organism
Alcaligenes faecalis
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system