KEGG   ENZYME: 1.4.99.3Help
Entry
EC 1.4.99.3                 Enzyme                                 
Name amine dehydrogenase;
methylamine dehydrogenase;
primary-amine dehydrogenase;
amine: (acceptor) oxidoreductase (deaminating);
primary-amine:(acceptor) oxidoreductase (deaminating)
Class Oxidoreductases;
Acting on the CH-NH2 group of donors;
With other acceptors
BRITE hierarchy
Sysname primary-amine:acceptor oxidoreductase (deaminating)
Reaction(IUBMB) RCH2NH2 + H2O + acceptor = RCHO + NH3 + reduced acceptor [RN:R01854]
Reaction(KEGG) R01854 > R00606
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Substrate RCH2NH2 [CPD:C00375];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product RCHO [CPD:C00071];
NH3 [CPD:C00014];
reduced acceptor [CPD:C00030]
Cofactor PQQ [CPD:C00113]
Comment A quinoprotein.
Pathway PATH: ec00680  Methane metabolism
Orthology KO: K08685  amine dehydrogenase
Genes PPG: PputGB1_2221 PputGB1_2224
PEN: PSEEN2552 PSEEN2555
PAT: Patl_0157 Patl_0160
REU: Reut_B4077 Reut_B4080
BUR: Bcep18194_B0601 Bcep18194_B0604
BCN: Bcen_3305 Bcen_3308
BCH: Bcen2424_5059 Bcen2424_5062
BCM: Bcenmc03_5222 Bcenmc03_5225
BCJ: BCAM2301 BCAM2304
BAM: Bamb_4469 Bamb_4472
BAC: BamMC406_4994 BamMC406_4997
BMU: Bmul_3580 Bmul_3583
BMJ: BMULJ_04934 BMULJ_04937
BPH: Bphy_3809 Bphy_3812
MPT: Mpe_A2653
AZO: azo1239(qhpA) azo2257(mauA) azo2260(mauB)
MFA: Mfla_0548 Mfla_0551
MMB: Mmol_1572 Mmol_1575
MEA: Mex_1p2770(mauB) Mex_1p2773(mauA)
MCH: Mchl_0562 Mchl_0565
CAK: Caul_0557 Caul_0560
PDE: Pden_4730 Pden_4733
HBA: Hbal_2737 Hbal_2741
NAR: Saro_1685 Saro_1688 Saro_3818 Saro_3821
SWI: Swit_3251 Swit_3254 Swit_4363 Swit_4365
GDI: GDI_1807(mauA)
GDJ: Gdia_0036 Gdia_2337
APT: APA01_04540 APA01_04570
RER: RER_53630
MIN: Minf_1997 Minf_2000
Taxonomy
Structures PDB: 1MAE  1MAF  1MDA  1MG2  1MG3  1PBY  2BBK  2GC4  2GC7  2J55  
     2J56  2J57  2MAD  2MTA  3C75  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:6246962]
de Beer R, Duine JA, Frank J, Large PJ.
The prosthetic group of methylamine dehydrogenase from Pseudomonas
AM1: evidence for a quinone structure.
Biochim. Biophys. Acta. 622 (1980) 370-4.
Pseudomonas sp.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4388687]
Eady RR, Large PJ.
Purification and properties of an amine dehydrogenase from
Pseudomonas AM1 and its role in growth on methylamine.
Biochem. J. 106 (1968) 245-55.
Pseudomonas sp.
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:5124384]
Eady RR, Large PJ.
Microbial oxidation of amines. Spectral and kinetic properties of
the primary amine dehydrogenase of Pseudomonas AM1.
Biochem. J. 123 (1971) 757-71.
Pseudomonas sp.
Other DBs ExplorEnz - The Enzyme Database: 1.4.99.3
IUBMB Enzyme Nomenclature: 1.4.99.3
ExPASy - ENZYME nomenclature database: 1.4.99.3
UM-BBD (Biocatalysis/Biodegradation Database): 1.4.99.3
BRENDA, the Enzyme Database: 1.4.99.3
CAS: 60496-14-2
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