KEGG   ENZYME: 1.5.1.1Help
Entry
EC 1.5.1.1                  Enzyme                                 

Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H];
Delta1-pyrroline-2-carboxylate reductase;
DELTA1-pyrroline-2-carboxylate reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
AbLhpI;
pyrroline-2-carboxylate reductase;
L-proline:NAD(P)+ 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
(1) L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+ [RN:R02201 R02203];
(2) L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]
Reaction(KEGG)
Substrate
L-pipecolate [CPD:C00408];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]
Product
1-piperideine-2-carboxylate [CPD:C04092];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]
Comment
The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
History
EC 1.5.1.1 created 1961, modified 2015
Pathway
ec00310  Lysine degradation
ec00330  Arginine and proline metabolism
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
Orthology
K19743  1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Genes
SOD: Sant_2254
PAZO: AYR47_02320
PCH: EY04_18125
PSES: PSCI_5175
PSIL: PMA3_09465
PSE: NH8B_0270
BMA: BMAA1290
BMV: BMASAVP1_0266
BML: BMA10229_0536
BMN: BMA10247_A1031
BMAL: DM55_4233
BMAE: DM78_3939
BMAQ: DM76_4933
BMAI: DM57_10585
BMAF: DM51_4945
BMAZ: BM44_4196
BMAB: BM45_3318
BPS: BPSS0940
BPSE: BDL_4230
BPSM: BBQ_5196
BPSU: BBN_4400
BPSD: BBX_6071
BPK: BBK_3495
BPSH: DR55_4394
BPSA: BBU_5089
BPSO: X996_4178
BUT: X994_6182
BTQ: BTQ_4743
BTJ: BTJ_5685
BTZ: BTL_4224
BTD: BTI_5755
BTV: BTHA_3733
BTHE: BTN_3467
BTHM: BTRA_4218
BTHA: DR62_3540
BTHL: BG87_4200
BOK: DM82_5110
BOC: BG90_5484
BVE: AK36_4029
BCN: Bcen_4010
BCJ: BCAM1485
BCEN: DM39_3532
BCEW: DM40_4351
BCEO: I35_5339
BAM: Bamb_3766
BMU: Bmul_4263
BMK: DM80_3437
BMUL: NP80_4355
BCT: GEM_4275
BCED: DM42_3604
BDL: AK34_4045
BCON: NL30_05175
BUB: BW23_5154
BLAT: WK25_24125
BTEI: WS51_05030
BSEM: WJ12_27260
BPSL: WS57_06730
BMEC: WJ16_25790
BSTG: WT74_26205
BGU: KS03_5219
BGO: BM43_4860
BUK: MYA_4327
BUL: BW21_5442
BXE: Bxe_B1765
BXB: DR64_7069
BPH: Bphy_3343
BFN: OI25_4196
AMIM: MIM_c39830
BPSI: IX83_00760
ODI: ODI_R1977
AAV: Aave_3400
AAA: Acav_1835
MPT: Mpe_A1509
CFU: CFU_3543
CARE: LT85_4058
NET: Neut_2213
ZMO: ZMO1975
ZMN: Za10_1195
ZMB: ZZ6_1206
ZMI: ZCP4_1234
GOH: B932_1581
GXL: H845_2323
ASZ: ASN_1466(ocd)
AZL: AZL_d02350(ocd)
 » show all
Taxonomy
Reference
1  [PMID:13502341]
  Authors
MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.
  Title
Enzymatic synthesis of L-pipecolic acid and L-proline.
  Journal
J. Biol. Chem. 229 (1957) 789-800.
Reference
2  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and  Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline  metabolism of bacteria.
  Journal
FEBS. Open. Bio. 4 (2014) 240-50.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.1
IUBMB Enzyme Nomenclature: 1.5.1.1
ExPASy - ENZYME nomenclature database: 1.5.1.1
BRENDA, the Enzyme Database: 1.5.1.1
CAS: 9029-16-7

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