KEGG   ENZYME: 1.5.1.1Help
Entry
EC 1.5.1.1                  Enzyme                                 

Name
pyrroline-2-carboxylate reductase;
Delta1-pyrroline-2-carboxylate reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-proline:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]
Reaction(KEGG)
Substrate
L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
1-pyrroline-2-carboxylate [CPD:C03564];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces 1-pyrroline-2-carboxylate to L-proline and also 1,2-didehydropiperidine-2-carboxylate to L-pipecolate.
History
EC 1.5.1.1 created 1961
Pathway
Lysine degradation
Arginine and proline metabolism
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Reference
1  [PMID:13502341]
  Authors
MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.
  Title
Enzymatic synthesis of L-pipecolic acid and L-proline.
  Journal
J. Biol. Chem. 229 (1957) 789-800.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-16-7

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