KEGG ENZYME: 1.5.1.1

ENZYME: 1.5.1.1

Entry

EC 1.5.1.1 Enzyme

Name

pyrroline-2-carboxylate reductase;
Delta1-pyrroline-2-carboxylate reductase

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-proline:NAD(P)+ 2-oxidoreductase

Reaction(IUBMB)

L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]

Reaction(KEGG)

R01246 R01249;
(other) R02201 R02203

Substrate

L-proline [CPD:C00148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

1-pyrroline-2-carboxylate [CPD:C03564];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Reduces 1-pyrroline-2-carboxylate to L-proline and also 1,2-didehydropiperidine-2-carboxylate to L-pipecolate.

Pathway

ec00310	Lysine degradation
ec00330	Arginine and proline metabolism
ec00960	Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100	Metabolic pathways

Reference

1 [PMID:13502341]

Authors

MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.

Title

Enzymatic synthesis of L-pipecolic acid and L-proline.

Journal

J. Biol. Chem. 229 (1957) 789-800.

Organism

Rattus norvegicus [GN:rno]

Other DBs

ExplorEnz - The Enzyme Database:

1.5.1.1

IUBMB Enzyme Nomenclature:

1.5.1.1

ExPASy - ENZYME nomenclature database:

1.5.1.1

BRENDA, the Enzyme Database:

1.5.1.1

CAS:

9029-16-7

All links

Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (9)   
   KEGG REACTION (4)   
   KEGG RPAIR (4)   
   KEGG RCLASS (1)   
Genome (1)   
   KEGG GENOME (1)   
Protein sequence (11)   
   UniProt (5)   
   RefSeq(pep) (6)   
DNA sequence (15)   
   RefSeq(nuc) (7)   
   GenBank (4)   
   EMBL (4)   
Literature (1)   
   PubMed (1)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (58)   

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