KEGG   ENZYME: 1.5.1.1Help
Entry
EC 1.5.1.1                  Enzyme                                 

Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H];
Delta1-pyrroline-2-carboxylate reductase;
DELTA1-pyrroline-2-carboxylate reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
AbLhpI;
pyrroline-2-carboxylate reductase;
L-proline:NAD(P)+ 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-pipecolate/L-proline:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
(1) L-pipecolate + NAD(P)+ = 1-piperideine-2-carboxylate + NAD(P)H + H+ [RN:R02201 R02203];
(2) L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+ [RN:R01246 R01249]
Reaction(KEGG)
Substrate
L-pipecolate [CPD:C00408];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]
Product
1-piperideine-2-carboxylate [CPD:C04092];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]
Comment
The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
History
EC 1.5.1.1 created 1961, modified 2015
Pathway
Lysine degradation
Arginine and proline metabolism
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Orthology
K19743  
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Genes
SOD: 
PCH: 
PSES: 
PSE: 
BMA: 
BMV: 
BML: 
BMN: 
BMAL: 
BMAE: 
BMAQ: 
BMAI: 
BMAF: 
BMAZ: 
BMAB: 
BPS: 
BPM: 
BPL: 
BPD: 
BPSE: 
BPSM: 
BPSU: 
BPSD: 
BPZ: 
BPQ: 
BPK: 
BPSH: 
BPSA: 
BPSO: 
BUT: 
BTE: 
BTQ: 
BTJ: 
BTZ: 
BTD: 
BTV: 
BTHE: 
BTHM: 
BTHA: 
BTHL: 
BOK: 
BOC: 
BVI: 
BVE: 
BUR: 
BCN: 
BCH: 
BCM: 
BCJ: 
BCEN: 
BCEW: 
BCEO: 
BAM: 
BAC: 
BMU: 
BMK: 
BMUL: 
BCT: 
BCED: 
BDL: 
BPYR: 
BCON: 
BGL: 
BGP: 
BGU: 
BUG: 
BGE: 
BGF: 
BGD: 
BGO: 
BYI: 
BUK: 
BUO: 
BUE: 
BUL: 
BUB: 
BUQ: 
BPLA: 
BUD: 
BXE: 
BXB: 
BPH: 
BPX: 
BPY: 
BFN: 
BCAI: 
AKA: 
AMIM: 
CDN: 
BPSI: 
AFA: 
AAV: 
AAA: 
MPT: 
HSE: 
HHT: 
HRB: 
CFU: 
CARE: 
CPRA: 
RDP: 
PKT: 
MIU: 
NET: 
ZMO: 
ZMN: 
ZMB: 
ZMI: 
ZMC: 
ZMR: 
GOH: 
GXL: 
APT: 
APW: 
APF: 
APU: 
APG: 
APQ: 
APX: 
APZ: 
APK: 
ASZ: 
AZL: 
ALI: 
ATI: 
OPR: 
 » show all
Taxonomy
Reference
1  [PMID:13502341]
  Authors
MEISTER A, RADHAKRISHNAN AN, BUCKLEY SD.
  Title
Enzymatic synthesis of L-pipecolic acid and L-proline.
  Journal
J. Biol. Chem. 229 (1957) 789-800.
Reference
2  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and  Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline  metabolism of bacteria.
  Journal
FEBS. Open. Bio. 4 (2014) 240-50.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-16-7

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