KEGG   ENZYME: 1.5.1.16Help
Entry
EC 1.5.1.16                 Enzyme                                 

Name
D-lysopine dehydrogenase;
D-lysopine synthase;
lysopine dehydrogenase;
D(+)-lysopine dehydrogenase;
2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
Reaction(IUBMB)
N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O = L-lysine + pyruvate + NADPH + H+ [RN:R00452]
Reaction(KEGG)
Substrate
N2-(D-1-carboxyethyl)-L-lysine [CPD:C04020];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-lysine [CPD:C00047];
pyruvate [CPD:C00022];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse reaction, a number of L-amino acids can act instead of L-lysine, and 2-oxobutanoate and, to a lesser extent, glyoxylate can act instead of pyruvate.
History
EC 1.5.1.16 created 1978
Pathway
Lysine degradation
Reference
1  [PMID:21695]
  Authors
Otten LA, Vreugdenhil D, Schilperoort RA.
  Title
Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue.
  Journal
Biochim. Biophys. Acta. 485 (1977) 268-77.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65187-41-9

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