KEGG   ENZYME: 1.5.1.21Help
Entry
EC 1.5.1.21                 Enzyme                                 

Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH);
Pyr2C reductase;
1,2-didehydropipecolate reductase;
P2C reductase;
1,2-didehydropipecolic reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
L-pipecolate:NADP+ 2-oxidoreductase;
DELTA1-piperideine-2-carboxylate reductase;
Delta1-piperideine-2-carboxylate reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-pipecolate/L-proline:NADP+ 2-oxidoreductase
Reaction(IUBMB)
(1) L-pipecolate + NADP+ = 1-piperideine-2-carboxylate + NADPH + H+ [RN:R02203];
(2) L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+ [RN:R01249]
Reaction(KEGG)
Substrate
L-pipecolate [CPD:C00408];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]
Product
1-piperideine-2-carboxylate [CPD:C04092];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]
Comment
The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH.
History
EC 1.5.1.21 created 1984 (EC 1.5.1.14 created 1976, incorporated 1989), modified 2015
Pathway
Lysine degradation
Tropane, piperidine and pyridine alkaloid biosynthesis
Metabolic pathways
Orthology
K13609  
delta1-piperideine-2-carboxylate reductase
Genes
PPU: 
PPF: 
PPG: 
PPW: 
PPT: 
PPB: 
PPI: 
PPX: 
PPUH: 
PPUT: 
PPUN: 
PPUD: 
PMON: 
PMOT: 
PMOS: 
PPJ: 
PST: 
PSB: 
PSYR: 
PSP: 
PCI: 
PFL: 
PPRC: 
PPRO: 
PFO: 
PFS: 
PFE: 
PFC: 
PFN: 
PFW: 
PFB: 
PFF: 
PPZ: 
PMAN: 
PTV: 
PEN: 
PBA: 
PBC: 
PPUU: 
PSV: 
PSK: 
PCH: 
PCZ: 
PCP: 
PFZ: 
PALK: 
PRH: 
PSW: 
PPV: 
PSEM: 
PSEC: 
PPSY: 
PSOS: 
BPE: 
BPC: 
BPER: 
BPET: 
BPEU: 
BPA: 
BPAR: 
BBR: 
BBM: 
BBH: 
BBX: 
AJS: 
DIA: 
ARA: 
AVI: 
PHL: 
DEQ: 
KVU: 
KVL: 
SSAN: 
ABS: 
ABQ: 
APM: 
BLY: 
 » show all
Taxonomy
Reference
1  [PMID:6801013]
  Authors
Payton CW, Chang YF.
  Title
delta1-piperideine-2-carboxylate reductase of Pseudomonas putida.
  Journal
J. Bacteriol. 149 (1982) 864-71.
Reference
2  [PMID:15561717]
  Authors
Muramatsu H, Mihara H, Kakutani R, Yasuda M, Ueda M, Kurihara T, Esaki N
  Title
The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline.
  Journal
J. Biol. Chem. 280 (2005) 5329-35.
  Sequence
Reference
3  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and  Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline  metabolism of bacteria.
  Journal
FEBS. Open. Bio. 4 (2014) 240-50.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52037-88-4

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