KEGG   ENZYME: 1.5.1.27Help
Entry
EC 1.5.1.27                 Enzyme                                 

Name
1,2-dehydroreticulinium reductase (NADPH);
1,2-dehydroreticulinium ion reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-reticuline:NADP+ oxidoreductase
Reaction(IUBMB)
(R)-reticuline + NADP+ = 1,2-dehydroreticulinium + NADPH + H+ [RN:R04695]
Reaction(KEGG)
Substrate
(R)-reticuline [CPD:C05178];
NADP+ [CPD:C00006]
Product
1,2-dehydroreticulinium [CPD:C06167];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions.
History
EC 1.5.1.27 created 1999, modified 2004
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1
  Authors
De-Eknamkul, W. and Zenk, M.H.
  Title
Purification and properties of 1,2-dehydroreticulinium reductase from Papaver somniferum seedlings.
  Journal
Phytochemistry 31 (1992) 813-821.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
130590-58-8

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