KEGG   ENZYME: 1.5.1.31Help
Entry
EC 1.5.1.31                 Enzyme                                 

Name
berberine reductase;
(R)-canadine synthase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-tetrahydroberberine:NADP+ oxidoreductase
Reaction(IUBMB)
(R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+ [RN:R07169]
Reaction(KEGG)
Substrate
(R)-canadine [CPD:C11818];
NADP+ [CPD:C00006]
Product
berberine [CPD:C00757];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 1.3.3.8 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.
History
EC 1.5.1.31 created 2002
Pathway
Isoquinoline alkaloid biosynthesis
Reference
1
  Authors
Bauer, W. and Zenk, M.H.
  Title
Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro.
  Journal
Tetrahedron Lett. 32 (1991) 487-490.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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