KEGG   ENZYME: 1.5.1.42Help
Entry
EC 1.5.1.42                 Enzyme                                 

Name
FMN reductase (NADH);
NADH-FMN reductase;
NADH-dependent FMN reductase;
NADH:FMN oxidoreductase;
NADH:flavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
FMNH2:NAD+ oxidoreductase
Reaction(IUBMB)
FMNH2 + NAD+ = FMN + NADH + H+ [RN:R05705]
Reaction(KEGG)
Substrate
FMNH2 [CPD:C01847];
NAD+ [CPD:C00003]
Product
FMN [CPD:C00061];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme often forms a two-component system with monooxygenases. Unlike EC 1.5.1.38, FMN reductase (NADPH), and EC 1.5.1.39, FMN reductase [NAD(P)H], this enzyme has a strong preference for NADH over NADPH, although some activity with the latter is observed [1,2].
While FMN is the preferred substrate, FAD can also be used with much lower activity [1,3].
History
EC 1.5.1.42 created 2011
Pathway
Riboflavin metabolism
Metabolic pathways
Orthology
K20146  
nitrilotriacetate monooxygenase reductase component
Reference
1  [PMID:47604]
  Authors
Duane W, Hastings JW.
  Title
Flavin mononucleotide reductase of luminous bacteria.
  Journal
Mol. Cell. Biochem. 6 (1975) 53-64.
Reference
2  [PMID:1175652]
  Authors
Gerlo E, Charlier J
  Title
Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi.
  Journal
Eur. J. Biochem. 57 (1975) 461-7.
Reference
3  [PMID:1735711]
  Authors
Uetz T, Schneider R, Snozzi M, Egli T
  Title
Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600.
  Journal
J. Bacteriol. 174 (1992) 1179-88.
  Sequence
Reference
4  [PMID:8167139]
  Authors
Izumoto Y, Mori T, Yamamoto K
  Title
Cloning and nucleotide sequence of the gene for NADH:FMN oxidoreductase from Vibrio harveyi.
  Journal
Biochim. Biophys. Acta. 1185 (1994) 243-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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