KEGG   ENZYME: 1.5.1.43Help
Entry
EC 1.5.1.43                 Enzyme                                 

Name
carboxynorspermidine synthase;
carboxynorspermidine dehydrogenase;
carboxyspermidine dehydrogenase;
CASDH;
CANSDH;
VC1624 (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
carboxynorspermidine:NADP+ oxidoreductase
Reaction(IUBMB)
(1) carboxynorspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ [RN:R09080];
(2) carboxyspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + putrescine + NADPH + H+ [RN:R09079]
Reaction(KEGG)
Substrate
carboxynorspermidine [CPD:C18174];
H2O [CPD:C00001];
NADP+ [CPD:C00006];
carboxyspermidine [CPD:C18172]
Product
L-aspartate 4-semialdehyde [CPD:C00441];
propane-1,3-diamine [CPD:C00986];
NADPH [CPD:C00005];
H+ [CPD:C00080];
putrescine [CPD:C00134]
Comment
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3].
History
EC 1.5.1.43 created 2012
Pathway
Arginine and proline metabolism
Metabolic pathways
Orthology
K13746  
carboxynorspermidine synthase
Genes
VCH: 
VCF: 
VCE: 
VCJ: 
VCO: 
VCR: 
VCM: 
VCI: 
VCL: 
VCQ: 
VCS: 
VCX: 
VCZ: 
VVU: 
VVY: 
VVM: 
VVL: 
VPA: 
VPB: 
VPK: 
VPF: 
VPH: 
VHA: 
VCA: 
VAG: 
VSP: 
VEX: 
VEJ: 
VFU: 
VNI: 
VAN: 
LAG: 
VAU: 
VCY: 
VCT: 
VTU: 
VSA: 
AWD: 
PPR: 
PBPRA2229(RB1550)
PGB: 
GHO: 
PIN: 
PSY: 
MVS: 
 » show all
Taxonomy
Reference
1  [PMID:1955861]
  Authors
Nakao H, Shinoda S, Yamamoto S
  Title
Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus.
  Journal
J. Gen. Microbiol. 137 (1991) 1737-42.
Reference
2  [PMID:19196710]
  Authors
Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ.
  Title
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.
  Journal
J. Biol. Chem. 284 (2009) 9899-907.
  Sequence
[vch:VC1624]
Reference
3  [PMID:22025614]
  Authors
Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ
  Title
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
  Journal
J. Biol. Chem. 286 (2011) 43301-12.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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