KEGG   ENZYME: 1.5.1.45Help
Entry
EC 1.5.1.45                 Enzyme                                 

Name
FAD reductase [NAD(P)H];
GTNG_3158 (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
FADH2:NAD(P)+ oxidoreductase
Reaction(IUBMB)
FADH2 + NAD(P)+ = FAD + NAD(P)H + H+ [RN:R09520 R09748]
Reaction(KEGG)
Substrate
FADH2 [CPD:C01352];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
FAD [CPD:C00016];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC 1.14.14.8, anthranilate 3-monooxygenase (FAD). It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor. cf. EC 1.5.1.37, FAD reductase (NADH).
History
EC 1.5.1.45 created 2012
Orthology
K16902  
FAD reductase [NAD(P)H]
Genes
BMQ: 
BMD: 
GTN: 
GMC: 
Taxonomy
Reference
1  [PMID:19942660]
  Authors
Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L
  Title
Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.
  Journal
Microbiology. 156 (2010) 589-95.
  Sequence
[gtn:GTNG_3158]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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