KEGG   ENZYME: 1.5.1.48Help
Entry
EC 1.5.1.48                 Enzyme                                 

Name
2-methyl-1-pyrroline reductase;
(R)-imine reductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-2-methylpyrrolidine:NADP+ 2-oxidoreductase
Reaction(IUBMB)
(R)-2-methylpyrrolidine + NADP+ = 2-methyl-1-pyrroline + NADPH + H+ [RN:R10730]
Reaction(KEGG)
Substrate
(R)-2-methylpyrrolidine [CPD:C20809];
NADP+ [CPD:C00006]
Product
2-methyl-1-pyrroline [CPD:C20808];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Streptomyces sp. GF3587 is highly specific for its substrate and forms only the (R) isomer.
History
EC 1.5.1.48 created 2014
Orthology
K19809  
2-methyl-1-pyrroline reductase
Genes
SFI: 
Taxonomy
Reference
1  [PMID:21897027]
  Authors
Mitsukura K, Suzuki M, Shinoda S, Kuramoto T, Yoshida T, Nagasawa T
  Title
Purification and characterization of a novel (R)-imine reductase from Streptomyces sp. GF3587.
  Journal
Biosci. Biotechnol. Biochem. 75 (2011) 1778-82.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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