KEGG   ENZYME: 1.5.1.9Help
Entry
EC 1.5.1.9                  Enzyme                                 
Name
saccharopine dehydrogenase (NAD+, L-glutamate-forming);
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming);
saccharopin dehydrogenase;
NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming);
aminoadipic semialdehyde synthase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+ [RN:R02313]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The activities of this enzyme along with EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein.
Pathway
Lysine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00292  
saccharopine dehydrogenase (NAD+, L-glutamate forming)
K14157  
alpha-aminoadipic semialdehyde synthase
Genes
HSA: 
10157(AASS)
PTR: 
472493(AASS)
PPS: 
100983928(AASS)
GGO: 
101143865(AASS)
PON: 
100454072(AASS)
MCC: 
694594(AASS)
MMU: 
30956(Aass)
RNO: 
296925(Aass)
CFA: 
482429(AASS)
AML: 
FCA: 
101091272(AASS)
BTA: 
520865(AASS)
SSC: 
100513962(AASS)
ECB: 
100056260(AASS)
MDO: 
100016400(AASS)
SHR: 
100923009(AASS)
OAA: 
100076030
GGA: 
417757(AASS)
MGP: 
100543809
TGU: 
100222251(AASS)
ACS: 
100553247
XLA: 
444409(aass)
XTR: 
496923(aass)
DRE: 
556229(aass)
TRU: 
101061348
OLA: 
101155996
BFO: 
BRAFLDRAFT_126942
SPU: 
592682
DME: 
Dmel_CG7144(LKR)
DPO: 
Dpse_GA20134
DAN: 
Dana_GF22842
DER: 
Dere_GG23507
DPE: 
Dper_GL18850
DSE: 
Dsec_GM13320
DSI: 
Dsim_GD22468
DWI: 
Dwil_GK15303
DYA: 
Dyak_GE18334
DGR: 
Dgri_GH11382
DMO: 
Dmoj_GI18086
DVI: 
Dvir_GJ16772
AGA: 
AgaP_AGAP008632
AAG: 
AaeL_AAEL014734
CQU: 
CpipJ_CPIJ000416
AME: 
552130(LKR)
NVI: 
100123521(NV14067)
TCA: 
660388
API: 
100163885 100166221
PHU: 
Phum_PHUM016080
ISC: 
IscW_ISCW008489
CEL: 
CELE_R02D3.1
CBR: 
CBG13546
NVE: 
NEMVE_v1g235305
HMG: 
100197048
TAD: 
TRIADDRAFT_36926
AQU: 
100641330
ALY: 
ARALYDRAFT_491371
GMX: 
100811246 100813294
MTR: 
MTR_4g124470
CSV: 
101214976
RCU: 
RCOM_0708300
POP: 
POPTR_739274
VVI: 
100268037
BDI: 
100824912
SBI: 
SORBI_04g035220(SORBIDRAFT_04g035220)
ZMA: 
541648(lkrsdh1)
SMO: 
SELMODRAFT_103525
PPP: 
PHYPADRAFT_107996
CNB: 
CNBA2210
CGI: 
CGB_B3130C
LBC: 
LACBIDRAFT_241294
CCI: 
CC1G_15806
SCM: 
SCHCODRAFT_68324
MBR: 
MONBRDRAFT_16322
NGR: 
NAEGRDRAFT_79185
DPP: 
DICPUDRAFT_51448
PTI: 
PHATRDRAFT_54394(LKRSDH)
TPS: 
THAPSDRAFT_261124
PIF: 
PITG_03530
PRW: 
PsycPRwf_2123
STP: 
Strop_3396
GFO: 
GFO_0103
 » show all
Taxonomy
Reference
1  [PMID:4385118]
  Authors
Hutzler J, Dancis J.
  Title
Conversion of lysine to saccharopine by human tissues.
  Journal
Biochim. Biophys. Acta. 158 (1968) 62-9.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:6434529]
  Authors
Markovitz PJ, Chuang DT, Cox RP.
  Title
Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
  Journal
J. Biol. Chem. 259 (1984) 11643-6.
  Organism
Bos taurus [GN:bta], Papio sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-26-1
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