KEGG   ENZYME: 1.5.3.12Help
Entry
EC 1.5.3.12                 Enzyme                                 

Name
dihydrobenzophenanthridine oxidase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
dihydrobenzophenanthridine:oxygen oxidoreductase
Reaction(IUBMB)
(1) dihydrosanguinarine + O2 = sanguinarine + H2O2 [RN:R04703];
(2) dihydrochelirubine + O2 = chelirubine + H2O2 [RN:R04706];
(3) dihydromacarpine + O2 = macarpine + H2O2 [RN:R04768]
Reaction(KEGG)
Substrate
dihydrosanguinarine [CPD:C05191];
O2 [CPD:C00007];
dihydrochelirubine [CPD:C05194];
dihydromacarpine [CPD:C05316]
Product
sanguinarine [CPD:C06162];
H2O2 [CPD:C00027];
chelirubine [CPD:C06327];
macarpine [CPD:C06165]
Comment
A CuII enzyme found in higher plants that produces oxidized forms of the benzophenanthridine alkaloids
History
EC 1.5.3.12 created 1999
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Reference
1
  Authors
Schumacher, H.-M. and Zenk, M.H.
  Title
Partial purification and characterization of dihydrobenzophenanthridine oxidase from Eschscholtzia tenuifolia cell suspension cultures.
  Journal
Plant Cell Reports 7 (1988) 43-46.
Reference
2  [PMID:1444440]
  Authors
Arakawa H, Clark WG, Psenak M, Coscia CJ.
  Title
Purification and characterization of dihydrobenzophenanthridine oxidase from elicited Sanguinaria canadensis cell cultures.
  Journal
Arch. Biochem. Biophys. 299 (1992) 1-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
114051-83-1

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