KEGG   ENZYME: 1.5.3.16Help
Entry
EC 1.5.3.16                 Enzyme                                 

Name
spermine oxidase;
PAOh1/SMO;
PAOh1 (ambiguous);
AtPAO1;
AtPAO4;
SMO;
mSMO;
SMO(PAOh1);
SMO/PAOh1;
SMO5;
mSMOmu
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
spermidine:oxygen oxidoreductase (spermidine-forming)
Reaction(IUBMB)
spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076]
Reaction(KEGG)
Substrate
spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027]
Comment
The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency [3]. The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC 1.5.3.17 (non-specific polyamine oxidase).
History
EC 1.5.3.16 created 2009
Pathway
Arginine and proline metabolism
beta-Alanine metabolism
Orthology
K12259  
spermine oxidase
K13366  
polyamine oxidase
Genes
HSA: 
54498(SMOX)
PTR: 
458074(SMOX)
PPS: 
100983105(SMOX)
GGO: 
101133425(SMOX)
PON: 
100462330(SMOX)
MCC: 
MCF: 
MMU: 
228608(Smox)
RNO: 
308652(Smox) 501620(RGD1564480)
CGE: 
100763379(Smox)
HGL: 
101707899(Smox)
TUP: 
102477539(SMOX)
CFA: 
485787(SMOX)
AML: 
100480545(SMOX)
FCA: 
101084867(SMOX)
PTG: 
102953447(SMOX)
BTA: 
527211(SMOX)
BOM: 
102278225(SMOX)
PHD: 
102342141(SMOX)
CHX: 
102176898(SMOX)
OAS: 
101118975(SMOX)
SSC: 
100152781(SMOX)
CFR: 
102519491(SMOX)
BACU: 
103015742(SMOX)
LVE: 
103072563(SMOX)
ECB: 
100052311(SMOX)
MYB: 
102248159(SMOX)
MYD: 
102768889(SMOX)
PALE: 
102891646(SMOX)
MDO: 
100030883(SMOX)
SHR: 
OAA: 
100085736(SMOX)
GGA: 
422934(SMOX)
MGP: 
100540689(SMOX)
APLA: 
101789809(SMOX)
TGU: 
100232049(SMOX)
FAB: 
101815717(SMOX)
PHI: 
102104257(SMOX)
FPG: 
101911959(SMOX)
FCH: 
102050731(SMOX)
CLV: 
102085808(SMOX)
ASN: 
102381757(SMOX)
AMJ: 
102561876(SMOX)
PSS: 
102458431(SMOX)
CMY: 
102934652(SMOX)
ACS: 
100556339(smox)
PBI: 
103052732(SMOX)
XLA: 
432246(smox)
XTR: 
733959(smox)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103181501(smox)
BFO: 
ISC: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT4G29720(PAO5) AT5G13700(PAO1)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0001s27060g(POPTRDRAFT_839752) POPTR_0006s15580g(POPTRDRAFT_561090) POPTR_0009s06330g POPTR_0012s08090g(POPTRDRAFT_422519) POPTR_0015s08590g(POPTRDRAFT_666455)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0710200-00(Os01g0710200) Os03t0193400-00(Os03g0193400) Os09t0368200-00(Os09g0368200) Os09t0368500-01(Os09g0368500)
OBR: 
BDI: 
SBI: 
SORBI_03g032650(SORBIDRAFT_03g032650) SORBI_07g005780(SORBIDRAFT_07g005780)
ZMA: 
SITA: 
ATR: 
s00025p00238590(AMTR_s00025p00238590) s00055p00213550(AMTR_s00055p00213550) s00058p00159400(AMTR_s00058p00159400) s00064p00094890(AMTR_s00064p00094890)
SMO: 
CSL: 
CVR: 
GSL: 
CCP: 
FGR: 
NHE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
ANI: 
AFM: 
AOR: 
AOR_1_560024(AO090010000340) AOR_1_898184(AO090009000545)
ANG: 
ANI_1_1218084(An09g02560) ANI_1_334114(An13g02480)
AFV: 
ACT: 
NFI: 
PCS: 
ABE: 
TVE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
BCOM: 
NPA: 
PPL: 
DSQ: 
SHS: 
PCO: 
GTR: 
LBC: 
MPR: 
MRR: 
SCM: 
CPUT: 
SLA: 
ACAN: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:18422650]
  Authors
Murray-Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero RA Jr
  Title
Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.
  Journal
FEBS. J. 275 (2008) 2795-806.
  Sequence
[hsa:54498]
Reference
2  [PMID:12458219]
  Authors
Cervelli M, Polticelli F, Federico R, Mariottini P
  Title
Heterologous expression and characterization of mouse spermine oxidase.
  Journal
J. Biol. Chem. 278 (2003) 5271-6.
Reference
3  [PMID:16778015]
  Authors
Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R
  Title
Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion.
  Journal
Plant. Physiol. 141 (2006) 1519-32.
  Sequence
[ath:AT5G13700]
Reference
4  [PMID:12727196]
  Authors
Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr
  Title
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.
  Journal
Biochem. Biophys. Res. Commun. 304 (2003) 605-11.
  Sequence
[hsa:54498]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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