KEGG   ENZYME: 1.5.3.18Help
Entry
EC 1.5.3.18                 Enzyme                                 

Name
L-saccharopine oxidase;
FAP2
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
L-saccharopine:oxygen oxidoreductase (L-glutamate forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + H2O + O2 = (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2 [RN:R09495]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
L-glutamate [CPD:C00025];
H2O2 [CPD:C00027]
Comment
The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD).
History
EC 1.5.3.18 created 2011
Orthology
K17833  
L-saccharopine oxidase
Genes
SPO: 
Taxonomy
Reference
1  [PMID:16233628]
  Authors
Yoshida N, Akazawa S, Katsuragi T, Tani Y
  Title
Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe.
  Journal
J. Biosci. Bioeng. 97 (2004) 278-80.
  Sequence
Reference
2  [PMID:2394693]
  Authors
Wickwire BM, Wagner C, Broquist HP.
  Title
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis.
  Journal
J. Biol. Chem. 265 (1990) 14748-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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