KEGG   ENZYME: 1.5.3.19Help
Entry
EC 1.5.3.19                 Enzyme                                 

Name
4-methylaminobutanoate oxidase (formaldehyde-forming);
mabO (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2 [RN:R10102]
Reaction(KEGG)
Substrate
4-methylaminobutanoate;
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
formaldehyde [CPD:C00067];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism.
History
EC 1.5.3.19 created 2012
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K19191  4-methylaminobutanoate oxidase (formaldehyde-forming)
Genes
PHD: 102338800
MHC: MARHY1152
HJA: BST95_16370
GAI: IMCC3135_07985(abo_2)
OAI: OLEAN_C33630
OME: OLMES_3997
TSN: W908_04065
REH: H16_B1955(gcvT3)
CNC: CNE_2c19180(gcvT)
CTI: RALTA_B1656
BGP: BGL_1c10300(sardh)
BGU: KS03_1930
BGO: BM43_2471
BXE: Bxe_B1666
BXB: DR64_6973
BPH: Bphy_3161
BFN: OI25_4099
PPNO: DA70_13465
PPNM: LV28_17235
PPUL: RO07_11360
PSPU: NA29_07175
PAPI: SG18_11740
LIM: L103DPR2_01233(mlr)
RGE: RGE_31450
SFD: USDA257_c17540(gcvT1) USDA257_c24400(gcvT2) USDA257_c45730(gcvT4)
SAME: SAMCFNEI73_Ch2543(gcvT)
ARA: Arad_3548
RLE: RL0097
RLG: Rleg_4350
MET: M446_3866
MSC: BN69_2738
HDI: HDIA_4735(gcvT_4)
RBM: TEF_03635
JAN: Jann_2849
RDE: RD1_0017
PDE: Pden_4916
PGD: Gal_03370
PHP: PhaeoP97_02079(sardh_1) PhaeoP97_03221(sardh_2)
PPIC: PhaeoP14_02119(sardh_1) PhaeoP14_03109(sardh_2)
OAT: OAN307_c43050(sardh2) OAN307_c46300(sardh1)
OAR: OA238_c40890(sardh)
OTM: OSB_30250(mlr_6)
PTP: RCA23_c00690(sardh)
RHC: RGUI_2285
RMM: ROSMUCSMR3_03063(abo)
MVA: Mvan_2290
MPH: MLP_04500
KAL: KALB_2196
PSL: Psta_3136
AALG: AREALGSMS7_02101(abo)
 » show all
Taxonomy
Reference
1  [PMID:15606755]
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism  of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur. J. Biochem. 271 (2004) 4677-84.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.19
IUBMB Enzyme Nomenclature: 1.5.3.19
ExPASy - ENZYME nomenclature database: 1.5.3.19
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.19
BRENDA, the Enzyme Database: 1.5.3.19

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