KEGG   ENZYME: 1.5.3.19Help
Entry
EC 1.5.3.19                 Enzyme                                 

Name
4-methylaminobutanoate oxidase (formaldehyde-forming);
mabO (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2 [RN:R10102]
Reaction(KEGG)
Substrate
4-methylaminobutanoate;
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
formaldehyde [CPD:C00067];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism.
History
EC 1.5.3.19 created 2012
Pathway
Nicotinate and nicotinamide metabolism
Reference
1  [PMID:15606755]
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism  of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur. J. Biochem. 271 (2004) 4677-84.
  Sequence
[up:Q8GAI3]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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