KEGG   ENZYME: 1.5.3.21Help
Entry
EC 1.5.3.21                 Enzyme                                 

Name
4-methylaminobutanoate oxidase (methylamine-forming);
mao (gene name, ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate methylamidohydrolase
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = succinate semialdehyde + methylamine + H2O2 [RN:R10101]
Reaction(KEGG)
Substrate
4-methylaminobutanoate;
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
succinate semialdehyde [CPD:C00232];
methylamine [CPD:C00218];
H2O2 [CPD:C00027]
Comment
The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC 1.4.3.4) activity with 4-aminobutanoate [1].
History
EC 1.5.3.21 created 2012
Pathway
Nicotinate and nicotinamide metabolism
Reference
1  [PMID:15606755]
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism  of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur. J. Biochem. 271 (2004) 4677-84.
Reference
2  [PMID:16689938]
  Authors
Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R
  Title
Final steps in the catabolism of nicotine.
  Journal
FEBS. J. 273 (2006) 1528-36.
  Sequence
[up:Q8GAJ0]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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