KEGG   ENZYME: 1.5.3.22Help
Entry
EC 1.5.3.22                 Enzyme                                 

Name
coenzyme F420H2 oxidase;
FprA
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
reduced coenzyme F420:oxygen oxidoreductase
Reaction(IUBMB)
2 reduced coenzyme F420 + O2 = 2 oxidized coenzyme F420 + 2 H2O [RN:R10602]
Reaction(KEGG)
Substrate
reduced coenzyme F420 [CPD:C01080];
O2 [CPD:C00007]
Product
oxidized coenzyme F420 [CPD:C00876];
H2O [CPD:C00001]
Comment
The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F420 [2].
History
EC 1.5.3.22 created 2013
Orthology
K19817  
coenzyme F420H2 oxidase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MAE: 
MVN: 
MVO: 
MOK: 
MTH: 
MMG: 
METC: 
MSI: 
MRU: 
mru_0131(fprA2)
MEB: 
Abm4_1680(fprA2)
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MFV: 
 » show all
Taxonomy
Reference
1  [PMID:15340796]
  Authors
Seedorf H, Dreisbach A, Hedderich R, Shima S, Thauer RK
  Title
F420H2 oxidase (FprA) from Methanobrevibacter arboriphilus, a coenzyme F420-dependent enzyme involved in O2 detoxification.
  Journal
Arch. Microbiol. 182 (2004) 126-37.
  Sequence
Reference
2  [PMID:16218963]
  Authors
Seedorf H, Kahnt J, Pierik AJ, Thauer RK
  Title
Si-face stereospecificity at C5 of coenzyme F420 for F420H2 oxidase from methanogenic Archaea as determined by mass spectrometry.
  Journal
FEBS. J. 272 (2005) 5337-42.
Reference
3  [PMID:17480207]
  Authors
Seedorf H, Hagemeier CH, Shima S, Thauer RK, Warkentin E, Ermler U
  Title
Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O.
  Journal
FEBS. J. 274 (2007) 1588-99.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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