KEGG   ENZYME: 1.5.3.6Help
Entry
EC 1.5.3.6                  Enzyme                                 

Name
(R)-6-hydroxynicotine oxidase;
D-6-hydroxynicotine oxidase;
6-hydroxy-D-nicotine oxidase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
(R)-6-hydroxynicotine:oxygen oxidoreductase
Reaction(IUBMB)
(R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 [RN:R07170]
Reaction(KEGG)
Substrate
(R)-6-hydroxynicotine [CPD:C03043];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD:C01297];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD).
History
EC 1.5.3.6 created 1972
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Reference
1  [PMID:4628374]
  Authors
Bruhmuller M, Mohler H, Decker K.
  Title
Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase.
  Journal
Eur. J. Biochem. 29 (1972) 143-51.
Reference
2  [PMID:5849820]
  Authors
Decker K, Bleeg H.
  Title
Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans.
  Journal
Biochim. Biophys. Acta. 105 (1965) 313-24.
Reference
3  [PMID:16095622]
  Authors
Koetter JW, Schulz GE
  Title
Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans.
  Journal
J. Mol. Biol. 352 (2005) 418-28.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37233-46-8

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