KEGG   ENZYME: 1.5.7.1Help
Entry
EC 1.5.7.1                  Enzyme                                 

Name
methylenetetrahydrofolate reductase (ferredoxin);
5,10-methylenetetrahydrofolate reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
5-methyltetrahydrofolate:ferredoxin oxidoreductase
Reaction(IUBMB)
5-methyltetrahydrofolate + 2 oxidized ferredoxin = 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H+ [RN:R01217]
Reaction(KEGG)
Substrate
5-methyltetrahydrofolate [CPD:C00440];
oxidized ferredoxin [CPD:C00139]
Product
5,10-methylenetetrahydrofolate [CPD:C00143];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
An iron-sulfur flavoprotein that also contains zinc. The enzyme from Clostridium formicoaceticum catalyses the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH2 with 5,10-methylenetetrahydrofolate. However, unlike EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H], there is no activity with NAD(P)H.
History
EC 1.5.7.1 created 2005
Pathway
One carbon pool by folate
Metabolic pathways
Reference
1  [PMID:6381490]
  Authors
Clark JE, Ljungdahl LG.
  Title
Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum.
  Journal
J. Biol. Chem. 259 (1984) 10845-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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