KEGG   ENZYME: 1.5.8.3Help
Entry
EC 1.5.8.3                  Enzyme                                 

Name
sarcosine dehydrogenase;
sarcosine N-demethylase;
monomethylglycine dehydrogenase;
sarcosine:(acceptor) oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
BRITE hierarchy
Sysname
sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating)
Reaction(IUBMB)
sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein [RN:R00611]
Reaction(KEGG)
Substrate
sarcosine [CPD:C00213];
H2O [CPD:C00001];
electron-transfer flavoprotein [CPD:C04253]
Product
glycine [CPD:C00037];
formaldehyde [CPD:C00067];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
A flavoprotein (FMN). Tetrahydrofolate is also a substrate, being converted to N5,N10-methylenetetrahydrofolate.
History
EC 1.5.8.3 created 1972 as EC 1.5.99.1, transferred 2012 to EC 1.5.8.3
Pathway
Glycine, serine and threonine metabolism
Metabolic pathways
Orthology
K00314  
sarcosine dehydrogenase
Genes
HSA: 
1757(SARDH)
PTR: 
464828(SARDH)
PPS: 
100986136(SARDH)
GGO: 
101126679(SARDH)
PON: 
100172073(SARDH)
NLE: 
100581547(SARDH)
MCC: 
713289(SARDH)
MCF: 
102139165(SARDH)
RRO: 
104669713(SARDH)
CJC: 
100396240(SARDH)
MMU: 
192166(Sardh)
RNO: 
114123(Sardh)
CGE: 
NGI: 
103742819(Sardh)
HGL: 
101717296(Sardh)
OCU: 
TUP: 
102468288(SARDH)
CFA: 
491277(SARDH)
AML: 
100477821(SARDH)
UMR: 
103679941(SARDH)
FCA: 
101082702(SARDH)
PTG: 
BTA: 
614603(SARDH)
BOM: 
102286478(SARDH)
PHD: 
102331084(SARDH)
CHX: 
102176539(SARDH)
OAS: 
101110407(SARDH)
SSC: 
100154338(SARDH)
CFR: 
BACU: 
103001806(SARDH)
LVE: 
103082579(SARDH)
ECB: 
100069193(SARDH)
MYB: 
102263827(SARDH)
MYD: 
102763367(SARDH)
PALE: 
102882489(SARDH)
MDO: 
100018850(SARDH)
SHR: 
100925921(SARDH)
OAA: 
100073946(SARDH)
GGA: 
417146(SARDH)
MGP: 
100544931(SARDH)
CJO: 
107321866(SARDH)
APLA: 
101793569(SARDH)
TGU: 
100221431(SARDH)
GFR: 
102042792(SARDH)
FAB: 
101807275(SARDH)
PHI: 
102100623(SARDH)
CCW: 
104688488(SARDH)
FPG: 
101910621(SARDH)
FCH: 
102055614(SARDH)
CLV: 
102089708(SARDH)
AAM: 
106484478(SARDH)
ASN: 
102387705(SARDH)
AMJ: 
102565496(SARDH)
PSS: 
102455800(SARDH)
CMY: 
102936719(SARDH)
ACS: 
100567227(sardh) 103281982(sardh)
PBI: 
GJA: 
107106570(SARDH)
XTR: 
100492087(sardh)
DRE: 
394103(sardh)
TRU: 
101066393(sardh)
MZE: 
101464347(sardh)
OLA: 
XMA: 
102218956(sardh)
LCM: 
102358838(SARDH)
CMK: 
103183089(sardh)
BFO: 
CIN: 
SPU: 
SKO: 
100374616(Sardh)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD25443(Dsim_GD25443)
DWI: 
DYA: 
Dyak_GE13964(dyak_GLEANR_14128)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
PHU: 
ISC: 
NVE: 
HMG: 
TAD: 
AFM: 
AAF: 
SPAR: 
EHX: 
RET: 
BME: 
 » show all
Taxonomy
Reference
1  [PMID:13716069]
  Authors
HOSKINS DD, MACKENZIE CG.
  Title
Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J. Biol. Chem. 236 (1961) 177-83.
Reference
2  [PMID:13895406]
  Authors
FRISELL WR, MACKENZIE CG.
  Title
Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J. Biol. Chem. 237 (1962) 94-8.
Reference
3  [PMID:6180732]
  Authors
Steenkamp DJ, Husain M
  Title
The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases.
  Journal
Biochem. J. 203 (1982) 707-15.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37228-65-2 93389-49-2

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