KEGG   ENZYME: 1.5.98.1Help
Entry
EC 1.5.98.1                 Enzyme                                 

Name
methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors
BRITE hierarchy
Sysname
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 [RN:R04456]
Reaction(KEGG)
Substrate
5,10-methylenetetrahydromethanopterin [CPD:C04377];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methenyltetrahydromethanopterin [CPD:C04330];
reduced coenzyme F420 [CPD:C01080]
Comment
Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.
History
EC 1.5.98.1 created 1989 as EC 1.5.99.9, modified 2004, transferred to EC 1.5.98.1 2014
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00319  methylenetetrahydromethanopterin dehydrogenase
Genes
MJA: MJ_1035
MFE: Mefer_1257
MVU: Metvu_0302
MFS: MFS40622_1652
MIF: Metin_0918
MJH: JH146_0907
MMP: MMP0372(mtd)
MMQ: MmarC5_1303
MMX: MmarC6_0579
MMZ: MmarC7_1368
MMD: GYY_01920
MAE: Maeo_1367
MVO: Mvol_1675
MAC: MA_4430(mtd)
MBAR: MSBR2_3303
MBAK: MSBR3_3304
MMA: MM_1108
MMAC: MSMAC_0200
METM: MSMTP_0225
MTHE: MSTHC_1565
MTHR: MSTHT_1723
MHOR: MSHOH_0247
MBU: Mbur_0929(mtd)
MMET: MCMEM_1436
MMH: Mmah_0679
MPY: Mpsy_1459
MTP: Mthe_0809
MCJ: MCON_1052(mtd)
MHI: Mhar_1470
MHU: Mhun_2255
MLA: Mlab_0079
MBG: BN140_1676(mtd)
MEMA: MMAB1_2159(mtd)
MPI: Mpet_2185
MBN: Mboo_0530
MPL: Mpal_0329
MPD: MCP_1313(mtd)
MEZ: Mtc_1592(mtd)
RCI: RCIX2230(mtd)
MTH: MTH_1464
MMG: MTBMA_c00500(mtd)
METC: MTCT_1331
MWO: MWSIV6_0005(mtd)
METE: tca_01413
MST: Msp_0163(mtd)
MSI: Msm_1204
MRU: mru_2142(mtd)
MEB: Abm4_0039(mtd)
MMIL: sm9_0086(mtd1) sm9_1352(mtd2)
MEYE: TL18_10280
MOL: YLM1_1676
METH: MBMB1_0003(mtd)
MFC: BRM9_0042(mtd)
MFI: DSM1535_1363(mtd)
MCUB: MCBB_0002(mtd)
MFV: Mfer_0811
MKA: MK0011(mtd)
AFU: AF_0714
FPL: Ferp_1018
GAC: GACE_0596
GAH: GAH_01690
LOKI: Lokiarch_17960(mtd)
 » show all
Taxonomy
Reference
1  [PMID:4084309]
  Authors
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI.
  Title
Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum.
  Journal
Biochem. Biophys. Res. Commun. 133 (1985) 884-90.
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim. Biophys. Acta. 1079 (1991) 293-302.
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.1
IUBMB Enzyme Nomenclature: 1.5.98.1
ExPASy - ENZYME nomenclature database: 1.5.98.1
BRENDA, the Enzyme Database: 1.5.98.1
CAS: 100357-01-5

DBGET integrated database retrieval system