KEGG   ENZYME: 1.5.98.1Help
Entry
EC 1.5.98.1                 Enzyme                                 

Name
methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors
BRITE hierarchy
Sysname
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 [RN:R04456]
Reaction(KEGG)
Substrate
5,10-methylenetetrahydromethanopterin [CPD:C04377];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methenyltetrahydromethanopterin [CPD:C04330];
reduced coenzyme F420 [CPD:C01080]
Comment
Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.
History
EC 1.5.98.1 created 1989 as EC 1.5.99.9, modified 2004, transferred to EC 1.5.98.1 2014
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00319  
methylenetetrahydromethanopterin dehydrogenase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MMP: 
MMP0372(mtd)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_4430(mtd)
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
MTH: 
MMG: 
METC: 
MST: 
MSI: 
MRU: 
MEB: 
MMIL: 
sm9_0086(mtd1) sm9_1352(mtd2)
MEYE: 
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MFV: 
MKA: 
MK0011(mtd)
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
LOKI: 
 » show all
Taxonomy
Reference
1  [PMID:4084309]
  Authors
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI.
  Title
Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum.
  Journal
Biochem. Biophys. Res. Commun. 133 (1985) 884-90.
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim. Biophys. Acta. 1079 (1991) 293-302.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
100357-01-5

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