KEGG   ENZYME: 1.5.98.2Help
Entry
EC 1.5.98.2                 Enzyme                                 

Name
5,10-methylenetetrahydromethanopterin reductase;
5,10-methylenetetrahydromethanopterin cyclohydrolase;
N5,N10-methylenetetrahydromethanopterin reductase;
methylene-H4MPT reductase;
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase;
N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors
BRITE hierarchy
Sysname
5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420 [RN:R04464]
Reaction(KEGG)
Substrate
5-methyltetrahydromethanopterin [CPD:C04488];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methylenetetrahydromethanopterin [CPD:C04377];
reduced coenzyme F420 [CPD:C01080]
Comment
Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea.
History
EC 1.5.98.2 created 2000 as EC 1.5.99.11, modified 2004, transferred to EC 1.5.98.2 2014
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00320  
5,10-methylenetetrahydromethanopterin reductase
Genes
RPB: 
SWI: 
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MSH: 
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MGO: 
MVQ: 
SVL: 
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SPRI: 
SLE: 
sle_06190(sle_06190)
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MIL: 
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MMP: 
MMP0058(mer)
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MVN: 
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MAC: 
MA_3733(mer)
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MTHR: 
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MMET: 
MMH: 
MEV: 
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MCJ: 
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RCI: 
RCIX564(mer)
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MFI: 
MFV: 
MKA: 
MK0524(mer)
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
HDL: 
HHB: 
HMA: 
rrnAC2437(mer1)
HHI: 
HAH_2870(mer3)
HHN: 
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NPH: 
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HUT: 
HTI: 
HMU: 
HJE: 
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HLA: 
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HLR: 
CSU: 
BARC: 
AOA65_0782(mer_2)
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:2379499]
  Authors
Ma K, Thauer RK.
  Title
Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur. J. Biochem. 191 (1990) 187-93.
  Sequence
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim. Biophys. Acta. 1079 (1991) 293-302.
Reference
3  [PMID:1696553]
  Authors
Ma K, Thauer RK.
  Title
Single step purification of methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum by specific binding to blue sepharose CL-6B.
  Journal
FEBS. Lett. 268 (1990) 59-62.
Reference
4  [PMID:2298726]
  Authors
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.
  Journal
J. Biol. Chem. 265 (1990) 1852-7.
  Sequence
[mth:MTH_1752]
Reference
5  [PMID:2298699]
  Authors
te Brommelstroet BW, Hensgens CM, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methenyltetrahydromethanopterin cyclohydrolase from Methanosarcina barkeri.
  Journal
J. Bacteriol. 172 (1990) 564-71.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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