KEGG   ENZYME: 1.5.99.11Help
Entry
EC 1.5.99.11                Enzyme                                 
Name
5,10-methylenetetrahydromethanopterin reductase;
5,10-methylenetetrahydromethanopterin cyclohydrolase;
N5,N10-methylenetetrahydromethanopterin reductase;
methylene-H4MPT reductase;
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase;
N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
BRITE hierarchy
Sysname
5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5-methyltetrahydromethanopterin + coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420 [RN:R04464]
Reaction(KEGG)
Substrate
5-methyltetrahydromethanopterin [CPD:C04488];
coenzyme F420 [CPD:C00876]
Product
5,10-methylenetetrahydromethanopterin [CPD:C04377];
reduced coenzyme F420 [CPD:C01080]
Comment
Catalyses an intermediate step in methanogenesis from CO2 and H2 in bacteria.
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00320  
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase
Genes
HOH: 
RPB: 
SWI: 
MAV: 
MSM: 
MJL: 
RHA: 
SRT: 
BCV: 
CFL: 
NCA: 
Noca_1630
SRO: 
Sros_6623
FAL: 
FRAAL3374 FRAL5465
SEN: 
SACE_2863
MAU: 
Micau_1979
MIL: 
ML5_2085
VMA: 
VAB18032_19125
RXY: 
Rxyl_0223
CWO: 
Cwoe_1775 Cwoe_4112
MJA: 
MJ_1534
MFE: 
Mefer_1535
MVU: 
Metvu_0160
MFS: 
MFS40622_0752
MIF: 
Metin_0159
MIG: 
Metig_1293
MMP: 
MMP0058(mer)
MMQ: 
MmarC5_1619
MMX: 
MmarC6_0892
MMZ: 
MmarC7_1055
MMD: 
GYY_00295
MAE: 
Maeo_0749
MVN: 
Mevan_1073
MVO: 
Mvol_1374
MOK: 
Metok_0200
MAC: 
MA3733(mer)
MBA: 
Mbar_A0254
MMA: 
MM_0628
MBU: 
Mbur_2372
MMH: 
Mmah_1513
MEV: 
Metev_2139
MZH: 
Mzhil_0168
MTP: 
Mthe_0205
MHU: 
Mhun_2257
MLA: 
Mlab_0076
MEM: 
Memar_0557
MPI: 
Mpet_2180
MBN: 
Mboo_0528
MPL: 
Mpal_0327
MPD: 
MCP_2681(mer)
MEZ: 
Mtc_0135(mer)
RCI: 
RCIX564(mer)
MTH: 
MTH1752
MMG: 
MTBMA_c03270(mer)
MST: 
Msp_1128(mer)
MSI: 
Msm_0542
MRU: 
mru_0569(mer)
MEL: 
Metbo_0510
MFV: 
Mfer_0274
MKA: 
MK0524(Mer)
AFU: 
AF1066(mer-1)
APO: 
Arcpr_1585
FPL: 
Ferp_0743
HMA: 
rrnAC2437(mer1)
HWA: 
HQ3154A(mer)
NPH: 
NP1056A
HLA: 
Hlac_1680
HUT: 
Huta_1395
HMU: 
Hmuk_0341
HTU: 
Htur_3573
NMG: 
Nmag_1582
HVO: 
HVO_1937(mer)
HJE: 
HacjB3_13295
HBO: 
Hbor_05330
HXA: 
Halxa_3407
 » show all
Taxonomy
Reference
1  [PMID:2379499]
  Authors
Ma K, Thauer RK.
  Title
Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur. J. Biochem. 191 (1990) 187-93.
  Organism
Methanobacterium thermoautotrophicum [GN:mth]
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim. Biophys. Acta. 1079 (1991) 293-302.
  Organism
Methanosarcina barkeri [GN:mba]
Reference
3  [PMID:1696553]
  Authors
Ma K, Thauer RK.
  Title
Single step purification of methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum by specific binding to blue sepharose CL-6B.
  Journal
FEBS. Lett. 268 (1990) 59-62.
  Organism
Methanobacterium thermoautotrophicum [GN:mth]
Reference
4  [PMID:2298726]
  Authors
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.
  Journal
J. Biol. Chem. 265 (1990) 1852-7.
  Organism
Methanobacterium thermoautotrophicum [GN:mth]
Reference
5  [PMID:2298699]
  Authors
te Brommelstroet BW, Hensgens CM, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
  Title
Purification and properties of 5,10-methenyltetrahydromethanopterin cyclohydrolase from Methanosarcina barkeri.
  Journal
J. Bacteriol. 172 (1990) 564-71.
  Organism
Methanosarcina barkeri [GN:mba]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system