KEGG   ENZYME: 1.5.99.11Help
Entry
EC 1.5.99.11                Enzyme                                 

Name 5,10-methylenetetrahydromethanopterin reductase;
5,10-methylenetetrahydromethanopterin cyclohydrolase;
N5,N10-methylenetetrahydromethanopterin reductase;
methylene-H4MPT reductase;
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin
reductase;
N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Class Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
BRITE hierarchy
Sysname 5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB) 5-methyltetrahydromethanopterin + coenzyme F420 =
5,10-methylenetetrahydromethanopterin + reduced coenzyme F420
[RN:R04464]
Reaction(KEGG) R04464
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Substrate 5-methyltetrahydromethanopterin [CPD:C04488];
coenzyme F420 [CPD:C00876]
Product 5,10-methylenetetrahydromethanopterin [CPD:C04377];
reduced coenzyme F420 [CPD:C01080]
Comment Catalyses an intermediate step in methanogenesis from CO2 and H2 in
bacteria.
Pathway PATH: ec00790  Folate biosynthesis
PATH: ec01100  Metabolic pathways
Orthology KO: K00320  coenzyme F420-dependent
            N5,N10-methenyltetrahydromethanopterin reductase
Genes RPB: RPB_4431
MAV: MAV_2543
MSM: MSMEG_2103 MSMEG_2456 MSMEG_3445
MJL: Mjls_3224
RHA: RHA1_ro00195 RHA1_ro00400 RHA1_ro01290 RHA1_ro01706
     RHA1_ro02495 RHA1_ro02649 RHA1_ro04686
NCA: Noca_1630
FAL: FRAAL3374 FRAL5465
SEN: SACE_2863
MJA: MJ0784 MJ1534
MMP: MMP0058(mer) MMP0127(hmd)
MMQ: MmarC5_1551 MmarC5_1619
MMX: MmarC6_0892
MMZ: MmarC7_1055
MAE: Maeo_0749
MVN: Mevan_1073
MAC: MA3733(mer)
MBA: Mbar_A0254
MMA: MM_0628
MBU: Mbur_2372
MTP: Mthe_0205
MHU: Mhun_2257
MLA: Mlab_0076 Mlab_1744
MEM: Memar_0557
MBN: Mboo_0528
MPL: Mpal_0327
MTH: MTH1142 MTH1752
MST: Msp_1128(mer)
MSI: Msm_0542
MKA: MK0013(hmd) MK0524(mer)
AFU: AF1066(mer-1)
HMA: rrnAC2437(mer1)
HWA: HQ3154A(mer)
NPH: NP1056A
HLA: Hlac_1680
HUT: Huta_1395
RCI: RCIX564(mer)
Taxonomy
Structures PDB: 1Z69  
Reference
  Authors
  Title


  Journal
  Organism
1  [PMID:2379499]
Ma K, Thauer RK.
Purification and properties of N5,
N10-methylenetetrahydromethanopterin reductase from Methanobacterium
thermoautotrophicum (strain Marburg).
Eur. J. Biochem. 191 (1990) 187-93.
Methanobacterium thermoautotrophicum [GN:mth]
Reference
  Authors

  Title


  Journal
  Organism
2  [PMID:1911853]
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels
GD.
Purification and properties of 5,10-methylenetetrahydromethanopterin
dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase,
two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
Biochim. Biophys. Acta. 1079 (1991) 293-302.
Methanosarcina barkeri [GN:mba]
Reference
  Authors
  Title


  Journal
  Organism
3  [PMID:1696553]
Ma K, Thauer RK.
Single step purification of methylenetetrahydromethanopterin
reductase from Methanobacterium thermoautotrophicum by specific
binding to blue sepharose CL-6B.
FEBS. Lett. 268 (1990) 59-62.
Methanobacterium thermoautotrophicum [GN:mth]
Reference
  Authors

  Title


  Journal
  Organism
4  [PMID:2298726]
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C,
Vogels GD.
Purification and properties of 5,10-methylenetetrahydromethanopterin
reductase, a coenzyme F420-dependent enzyme, from Methanobacterium
thermoautotrophicum strain delta H.
J. Biol. Chem. 265 (1990) 1852-7.
Methanobacterium thermoautotrophicum [GN:mth]
Reference
  Authors

  Title

  Journal
  Organism
5  [PMID:2298699]
te Brommelstroet BW, Hensgens CM, Geerts WJ, Keltjens JT, van der
Drift C, Vogels GD.
Purification and properties of 5,10-methenyltetrahydromethanopterin
cyclohydrolase from Methanosarcina barkeri.
J. Bacteriol. 172 (1990) 564-71.
Methanosarcina barkeri [GN:mba]
Other DBs ExplorEnz - The Enzyme Database: 1.5.99.11
IUBMB Enzyme Nomenclature: 1.5.99.11
ExPASy - ENZYME nomenclature database: 1.5.99.11
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.99.11
BRENDA, the Enzyme Database: 1.5.99.11

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