| Entry |
|
|---|
| Name |
5,10-methylenetetrahydromethanopterin reductase;
5,10-methylenetetrahydromethanopterin cyclohydrolase;
N5,N10-methylenetetrahydromethanopterin reductase;
methylene-H4MPT reductase;
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin
reductase;
N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
 |
|---|
| Sysname |
5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase |
|---|
| Reaction(IUBMB) |
5-methyltetrahydromethanopterin + coenzyme F420 =
5,10-methylenetetrahydromethanopterin + reduced coenzyme F420
[RN:R04464] |
|---|
| Reaction(KEGG) |
R04464
 |
|---|
| Substrate |
5-methyltetrahydromethanopterin [CPD:C04488];
coenzyme F420 [CPD:C00876] |
|---|
| Product |
5,10-methylenetetrahydromethanopterin [CPD:C04377];
reduced coenzyme F420 [CPD:C01080] |
|---|
| Comment |
Catalyses an intermediate step in methanogenesis from CO2 and H2 in
bacteria. |
|---|
| Pathway |
PATH: ec00790 Folate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00320 coenzyme F420-dependent
N5,N10-methenyltetrahydromethanopterin reductase |
|---|
| Genes |
RPB: RPB_4431
MAV: MAV_2543
MSM: MSMEG_2103 MSMEG_2456 MSMEG_3445
MJL: Mjls_3224
RHA: RHA1_ro00195 RHA1_ro00400 RHA1_ro01290 RHA1_ro01706
RHA1_ro02495 RHA1_ro02649 RHA1_ro04686
NCA: Noca_1630
FAL: FRAAL3374 FRAL5465
SEN: SACE_2863
MJA: MJ0784 MJ1534
MMP: MMP0058(mer) MMP0127(hmd)
MMQ: MmarC5_1551 MmarC5_1619
MMX: MmarC6_0892
MMZ: MmarC7_1055
MAE: Maeo_0749
MVN: Mevan_1073
MAC: MA3733(mer)
MBA: Mbar_A0254
MMA: MM_0628
MBU: Mbur_2372
MTP: Mthe_0205
MHU: Mhun_2257
MLA: Mlab_0076 Mlab_1744
MEM: Memar_0557
MBN: Mboo_0528
MPL: Mpal_0327
MTH: MTH1142 MTH1752
MST: Msp_1128(mer)
MSI: Msm_0542
MKA: MK0013(hmd) MK0524(mer)
AFU: AF1066(mer-1)
HMA: rrnAC2437(mer1)
HWA: HQ3154A(mer)
NPH: NP1056A
HLA: Hlac_1680
HUT: Huta_1395
RCI: RCIX564(mer)
 |
|---|
| Structures |
PDB: 1Z69 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2379499]
Ma K, Thauer RK.
Purification and properties of N5,
N10-methylenetetrahydromethanopterin reductase from Methanobacterium
thermoautotrophicum (strain Marburg).
Eur. J. Biochem. 191 (1990) 187-93.
Methanobacterium thermoautotrophicum [GN:mth] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1911853]
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels
GD.
Purification and properties of 5,10-methylenetetrahydromethanopterin
dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase,
two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
Biochim. Biophys. Acta. 1079 (1991) 293-302.
Methanosarcina barkeri [GN:mba] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:1696553]
Ma K, Thauer RK.
Single step purification of methylenetetrahydromethanopterin
reductase from Methanobacterium thermoautotrophicum by specific
binding to blue sepharose CL-6B.
FEBS. Lett. 268 (1990) 59-62.
Methanobacterium thermoautotrophicum [GN:mth] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:2298726]
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C,
Vogels GD.
Purification and properties of 5,10-methylenetetrahydromethanopterin
reductase, a coenzyme F420-dependent enzyme, from Methanobacterium
thermoautotrophicum strain delta H.
J. Biol. Chem. 265 (1990) 1852-7.
Methanobacterium thermoautotrophicum [GN:mth] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:2298699]
te Brommelstroet BW, Hensgens CM, Geerts WJ, Keltjens JT, van der
Drift C, Vogels GD.
Purification and properties of 5,10-methenyltetrahydromethanopterin
cyclohydrolase from Methanosarcina barkeri.
J. Bacteriol. 172 (1990) 564-71.
Methanosarcina barkeri [GN:mba] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.99.11
IUBMB Enzyme Nomenclature: 1.5.99.11
ExPASy - ENZYME nomenclature database: 1.5.99.11
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.99.11
BRENDA, the Enzyme Database: 1.5.99.11 |
|---|
