| Entry |
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| Name |
6-hydroxypseudooxynicotine dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
 |
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| Sysname |
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one:acceptor 6-oxidoreductase (hydroxylating)
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| Reaction(IUBMB) |
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + acceptor + H2O = 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced acceptor [RN: R07514]
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| Reaction(KEGG) |
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| Substrate |
1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD: C01297];
acceptor [CPD: C00028];
H2O [CPD: C00001]
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| Product |
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD: C15986];
reduced acceptor [CPD: C00030]
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| Comment |
Contains a cytidylyl molybdenum cofactor [3]. The enzyme, which participates in the nicotine degradation pathway, has been characterized from the soil bacterium Arthrobacter nicotinovorans [1,2].
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| Reference |
1 |
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| Authors |
Freudenberg, W., Konig, K. and Andreesen, J. R. |
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| Title |
Nicotine dehydrogenase from Arthrobacter oxidans: A molybdenum-containing hydroxylase. |
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| Journal |
FEMS Microbiology Letters 52 (1988) 13-18. |
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| Reference |
|
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| Authors |
Grether-Beck S, Igloi GL, Pust S, Schilz E, Decker K, Brandsch R |
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| Title |
Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans. |
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| Journal |
Mol. Microbiol. 13 (1994) 929-36. |
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| Reference |
|
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| Authors |
Sachelaru P, Schiltz E, Brandsch R |
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| Title |
A functional mobA gene for molybdopterin cytosine dinucleotide cofactor biosynthesis is required for activity and holoenzyme assembly of the heterotrimeric nicotine dehydrogenases of Arthrobacter nicotinovorans. |
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| Journal |
Appl. Environ. Microbiol. 72 (2006) 5126-31. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: |
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