KEGG   ENZYME: 1.5.99.5Help
Entry
EC 1.5.99.5                 Enzyme                                 

Name
methylglutamate dehydrogenase;
N-methylglutamate dehydrogenase;
N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)
Reaction(IUBMB)
N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor [RN:R00609]
Reaction(KEGG)
Substrate
N-methyl-L-glutamate [CPD:C01046];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
formaldehyde [CPD:C00067];
reduced acceptor [CPD:C00030]
Comment
A number of N-methyl-substituted amino acids can act as donor; 2,6-dichloroindophenol is the best acceptor.
History
EC 1.5.99.5 created 1976
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Orthology
K22084  
methylglutamate dehydrogenase subunit A
K22085  
methylglutamate dehydrogenase subunit B
K22086  
methylglutamate dehydrogenase subunit C
K22087  
methylglutamate dehydrogenase subunit D
Genes
MLO: 
MLN: 
MCI: 
MOP: 
MAM: 
MAMO: 
MESO: 
MESW: 
AAK: 
BRA: 
BRADO5878(soxB) BRADO5879(soxD) BRADO5880(soxA) BRADO5881(soxG)
BBT: 
BBta_1946(soxG) BBta_1947(soxA) BBta_1948(soxD) BBta_1949(soxB)
RPB: 
BOS: 
BVV: 
XAU: 
AZC: 
SNO: 
MEX: 
MEA: 
MDI: 
METDI2319(soxG) METDI2320(soxA) METDI2321(soxD) METDI2322(soxB)
MCH: 
MPO: 
META: 
MAQU: 
MZA: 
MSL: 
HDN: 
HDT: 
HMC: 
FIL: 
FIY: 
MCG: 
RBM: 
CAK: 
SSAN: 
ANH: 
GAL: 
GBE: 
GBH: 
GBC: 
GBS: 
GXL: 
KNA: 
KEU: 
AACE: 
RPM: 
AZL: 
 » show all
Taxonomy
Reference
1  [PMID:5028076]
  Authors
Hersh LB, Stark MJ, Worthen S, Fiero MK.
  Title
N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme.
  Journal
Arch. Biochem. Biophys. 150 (1972) 219-26.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37217-26-8

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