KEGG   ENZYME: 1.5.99.5Help
Entry
EC 1.5.99.5                 Enzyme                                 

Name
methylglutamate dehydrogenase;
N-methylglutamate dehydrogenase;
N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)
Reaction(IUBMB)
N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor [RN:R00609]
Reaction(KEGG)
Substrate
N-methyl-L-glutamate [CPD:C01046];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
formaldehyde [CPD:C00067];
reduced acceptor [CPD:C00030]
Comment
A number of N-methyl-substituted amino acids can act as donor; 2,6-dichloroindophenol is the best acceptor.
History
EC 1.5.99.5 created 1976
Pathway
Methane metabolism
Microbial metabolism in diverse environments
Reference
1  [PMID:5028076]
  Authors
Hersh LB, Stark MJ, Worthen S, Fiero MK.
  Title
N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme.
  Journal
Arch. Biochem. Biophys. 150 (1972) 219-26.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37217-26-8

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