KEGG   ENZYME: 1.5.99.6Help
Entry
EC 1.5.99.6                 Enzyme                                 

Name
spermidine dehydrogenase;
spermidine:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
spermidine:acceptor oxidoreductase
Reaction(IUBMB)
spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor [RN:R01915]
Reaction(KEGG)
Substrate
spermidine [CPD:C00315];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
propane-1,3-diamine [CPD:C00986];
4-aminobutanal [CPD:C00555];
reduced acceptor [CPD:C00030]
Comment
A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.
History
EC 1.5.99.6 created 1976
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K00316  spermidine dehydrogenase
Genes
ESA: ESA_01921
CSK: ES15_2077
CSZ: CSSP291_09175
CSI: P262_03032
CSJ: CSK29544_03197
CCON: AFK62_09295
CDM: AFK67_09545
CMJ: AFK66_010080
CUI: AFK65_09710
CMW: AFK63_09185
CTU: CTU_20670
YRU: BD65_631
SPE: Spro_3641
SPLY: Q5A_019235
SMAR: SM39_3239
SERF: L085_09905
EBI: EbC_23290
PAE: PA3713(spdH)
PAEV: N297_3837
PAEI: N296_3837
PAG: PLES_12691(spdH)
PAF: PAM18_1233(spdH)
PAEP: PA1S_06530
PAEM: U769_06320
PAEL: T223_06255
PAEU: BN889_04106(spdH)
PAEG: AI22_27060
PAEC: M802_3834
PAEO: M801_3702
PFS: PFLU_1208
PPUU: PputUW4_01030(spdH)
SAGA: M5M_17030
APAC: S7S_17560
AHA: AHA_2947
ASA: ASA_2962
AVR: B565_1361
CVI: CV_3055
REH: H16_A1592(h16_A1592)
RME: Rmet_1600
RGE: RGE_05530
CJI: CJSA_1098
CJEJ: N564_01122
CJEU: N565_01166
CJEN: N755_01160
CJEI: N135_01194
CLA: Cla_1077
CIS: CINS_1041
CVO: CVOL_1051
CPEL: CPEL_1181
SSY: SLG_33610
ASZ: ASN_2151(spdH)
SRO: Sros_0365
NJA: NSJP_0330
 » show all
Taxonomy
Reference
1  [PMID:4918845]
  Authors
Tabor CW, Kellogg PD.
  Title
Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens.
  Journal
J. Biol. Chem. 245 (1970) 5424-33.
Reference
2
  Authors
Tabor, H. and Tabor, C.W.
  Title
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase.
  Journal
Adv. Enzymol. Relat. Areas Mol. Biol. 36 (1972) 225-226.
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.6
IUBMB Enzyme Nomenclature: 1.5.99.6
ExPASy - ENZYME nomenclature database: 1.5.99.6
BRENDA, the Enzyme Database: 1.5.99.6
CAS: 9076-64-6

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