KEGG   ENZYME: 1.5.99.6Help
Entry
EC 1.5.99.6                 Enzyme                                 
Name
spermidine dehydrogenase;
spermidine:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
BRITE hierarchy
Sysname
spermidine:acceptor oxidoreductase
Reaction(IUBMB)
spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor [RN:R01915]
Reaction(KEGG)
Substrate
spermidine [CPD:C00315];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
propane-1,3-diamine [CPD:C00986];
4-aminobutanal [CPD:C00555];
reduced acceptor [CPD:C00030]
Comment
A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.
Pathway
Arginine and proline metabolism
beta-Alanine metabolism
Orthology
K00316  
spermidine dehydrogenase
Genes
EBI: 
ESA: 
CSK: 
CSZ: 
CTU: 
SPE: 
SRR: 
SRS: 
SRA: 
SMW: 
PAE: 
PA3713(spdH)
PAU: 
PA14_16360
PAP: 
PSPA7_1422
PAG: 
PLES_12691(spdH)
PAF: 
PAM18_1233(spdH)
PNC: 
NCGM2_4844
PDK: 
PADK2_05775
PSG: 
G655_06230
PPG: 
PputGB1_3728
PPUU: 
PputUW4_01030(spdH)
PFS: 
PFLU1208
AHA: 
AHA_2947
ASA: 
ASA_2962
AVR: 
B565_1361
SAGA: 
M5M_17030
GPB: 
HDN1F_23230
CVI: 
CV_3055
REU: 
Reut_A1454
REH: 
H16_A1592(h16_A1592)
RME: 
Rmet_1600
CTI: 
RALTA_A1519
CNC: 
CNE_1c16180
RGE: 
RGE_05530
CJI: 
CJSA_1098
CLA: 
Cla_1077
SSY: 
SLG_33610
SRO: 
Sros_0365
ABA: 
Acid345_1633
MSV: 
Mesil_3083
 » show all
Taxonomy
Reference
1  [PMID:4918845]
  Authors
Tabor CW, Kellogg PD.
  Title
Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens.
  Journal
J. Biol. Chem. 245 (1970) 5424-33.
  Organism
Serratia marcescens
Reference
2
  Authors
Tabor, H. and Tabor, C.W.
  Title
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase.
  Journal
Adv. Enzymol. Relat. Areas Mol. Biol. 36 (1972) 225-226.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9076-64-6
DBGET integrated database retrieval system