KEGG   ENZYME: 1.5.99.6Help
Entry
EC 1.5.99.6                 Enzyme                                 

Name
spermidine dehydrogenase;
spermidine:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
spermidine:acceptor oxidoreductase
Reaction(IUBMB)
spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor [RN:R01915]
Reaction(KEGG)
Substrate
spermidine [CPD:C00315];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
propane-1,3-diamine [CPD:C00986];
4-aminobutanal [CPD:C00555];
reduced acceptor [CPD:C00030]
Comment
A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.
History
EC 1.5.99.6 created 1976
Pathway
Arginine and proline metabolism
beta-Alanine metabolism
Orthology
K00316  
spermidine dehydrogenase
Genes
EBI: 
ESA: 
CSK: 
CSZ: 
CSI: 
CTU: 
CFD: 
SPE: 
SRR: 
SRL: 
SRY: 
SRS: 
SRA: 
SMW: 
SLQ: 
SFO: 
PAE: 
PA3713(spdH)
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PAEO: 
PPG: 
PPUU: 
PFS: 
AHA: 
AHY: 
AHD: 
ASA: 
AVR: 
SAGA: 
GPB: 
CVI: 
RPJ: 
REU: 
REH: 
H16_A1592(h16_A1592)
CNC: 
RME: 
CTI: 
RGE: 
CJI: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CLA: 
SSY: 
GXL: 
SRO: 
ABA: 
GBA: 
MSV: 
 » show all
Taxonomy
Reference
1  [PMID:4918845]
  Authors
Tabor CW, Kellogg PD.
  Title
Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens.
  Journal
J. Biol. Chem. 245 (1970) 5424-33.
  Organism
Serratia marcescens
Reference
2
  Authors
Tabor, H. and Tabor, C.W.
  Title
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase.
  Journal
Adv. Enzymol. Relat. Areas Mol. Biol. 36 (1972) 225-226.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9076-64-6

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