| Entry |
|
|---|
| Name |
methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase |
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With other acceptors
 |
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| Sysname |
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase |
|---|
| Reaction(IUBMB) |
5,10-methylenetetrahydromethanopterin + coenzyme F420 =
5,10-methenyltetrahydromethanopterin + reduced coenzyme F420
[RN:R04456] |
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| Reaction(KEGG) |
R04456
 |
|---|
| Substrate |
5,10-methylenetetrahydromethanopterin [CPD:C04377];
coenzyme F420 [CPD:C00876] |
|---|
| Product |
5,10-methenyltetrahydromethanopterin [CPD:C04330];
reduced coenzyme F420 [CPD:C01080] |
|---|
| Comment |
Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin
derivative; methanopterin is a pterin analogue. The enzyme is
involved in the formation of methane from CO2 in Methanobacterium
thermoautotrophicum. |
|---|
| Pathway |
PATH: ec00790 Folate biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00319 methylenetetrahydromethanopterin dehydrogenase |
|---|
| Genes |
MJA: MJ1035
MFE: Mefer_1257
MMP: MMP0372(mtd) MMP1716(hmdII)
MMQ: MmarC5_1303
MMX: MmarC6_0579
MMZ: MmarC7_1368
MAE: Maeo_1367
MVN: Mevan_1360
MAC: MA4430(mtd)
MBA: Mbar_A1095
MMA: MM_1108
MBU: Mbur_0929
MTP: Mthe_0809
MHU: Mhun_2255
MLA: Mlab_0079
MEM: Memar_0562
MBN: Mboo_0530
MPL: Mpal_0329
MTH: MTH1464
MST: Msp_0163(mtd)
MSI: Msm_1204
MKA: MK0011(mtd) MK1122(hmdIII) MK1365(hmdII)
AFU: AF0714(mtd)
RCI: RCIX2230(mtd)
 |
|---|
| Structures |
PDB: 1QV9 1U6I 1U6J 1U6K 3IQE 3IQF 3IQZ |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:4084309]
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI.
Coenzyme F420 dependence of the methylenetetrahydromethanopterin
dehydrogenase of Methanobacterium thermoautotrophicum.
Biochem. Biophys. Res. Commun. 133 (1985) 884-90.
Methanobacterium thermoautotrophicum [GN:mth] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1911853]
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels
GD.
Purification and properties of 5,10-methylenetetrahydromethanopterin
dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase,
two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
Biochim. Biophys. Acta. 1079 (1991) 293-302.
Methanosarcina barkeri [GN:mba] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.5.99.9
IUBMB Enzyme Nomenclature: 1.5.99.9
ExPASy - ENZYME nomenclature database: 1.5.99.9
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.99.9
BRENDA, the Enzyme Database: 1.5.99.9
CAS: 100357-01-5 |
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