KEGG   ENZYME: 1.6.3.5Help
Entry
EC 1.6.3.5                  Enzyme                                 

Name
renalase;
alphaNAD(P)H oxidase/anomerase (incorrect);
NAD(P)H:oxygen oxidoreductase (H2O2-forming, epimerising) (incorrect)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
BRITE hierarchy
Sysname
dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
Reaction(IUBMB)
(1) 1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 [RN:R10635 R10636];
(2) 1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2
Reaction(KEGG)
Substrate
1,2-dihydro-beta-NAD;
1,2-dihydro-beta-NAD(P);
H+ [CPD:C00080];
O2 [CPD:C00007];
1,6-dihydro-beta-NAD;
1,6-dihydro-beta-NAD(P)
Product
beta-NAD+ [CPD:C00003];
beta-NADP+ [CPD:C00006];
H2O2 [CPD:C00027]
Comment
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
History
EC 1.6.3.5 created 2014, modified 2015
Orthology
K18208  
renalase
Genes
HSA: 
55328(RNLS)
PTR: 
450581(RNLS)
PPS: 
100984167(RNLS)
GGO: 
101148106(RNLS)
PON: 
100442570(RNLS)
NLE: 
100606165(RNLS)
MCC: 
708585(RNLS)
MCF: 
102135381(RNLS)
CSAB: 
103216213(RNLS)
RRO: 
104675156(RNLS)
CJC: 
100394177(RNLS)
SBQ: 
101038706(RNLS)
MMU: 
67795(Rnls)
RNO: 
361751(Rnls)
CGE: 
NGI: 
103738043(Rnls)
HGL: 
101715856(Rnls)
OCU: 
100358976(RNLS)
TUP: 
102471808(RNLS)
CFA: 
610448(RNLS)
AML: 
100472491(RNLS)
UMR: 
103661923(RNLS)
FCA: 
101098402(RNLS)
PTG: 
102972926(RNLS)
BTA: 
534778(RNLS)
BOM: 
102268752(RNLS)
PHD: 
102342465(RNLS)
CHX: 
102186177(RNLS)
OAS: 
101119597(RNLS)
SSC: 
100155046(RNLS)
CFR: 
102514830(RNLS)
BACU: 
102997980(RNLS)
LVE: 
103074574(RNLS)
ECB: 
100062318(RNLS)
MYB: 
102258362(RNLS)
MYD: 
102755609(RNLS)
PALE: 
102881691(RNLS)
LAV: 
100660092(RNLS)
MDO: 
100012984(RNLS)
SHR: 
100921129(RNLS)
GGA: 
423674(RNLS)
MGP: 
104911888(RNLS)
CJO: 
107315644(RNLS)
APLA: 
101797594(RNLS)
TGU: 
100227044(RNLS)
GFR: 
102040917(RNLS)
FAB: 
101815597(RNLS)
PHI: 
102106894(RNLS)
CCW: 
104695102(RNLS)
FPG: 
101915468(RNLS)
FCH: 
102054531(RNLS)
CLV: 
102083736(RNLS)
AAM: 
106495311(RNLS)
ASN: 
102377193(RNLS)
AMJ: 
102559861(RNLS)
PSS: 
102457953(RNLS)
CMY: 
102941145(RNLS)
ACS: 
100555221(rnls)
PBI: 
103056270(RNLS)
GJA: 
XLA: 
447156(rnls)
XTR: 
100037883(rnls)
DRE: 
436880(rnls)
TNG: 
MZE: 
101479856(rnls)
OLA: 
101173449(rnls)
XMA: 
102217575(rnls)
SASA: 
LCM: 
102348794(RNLS)
CMK: 
103180807(rnls)
BFO: 
SPU: 
SKO: 
API: 
DPX: 
LGI: 
CRG: 
105341980(Renalase)
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
SMIN: 
v1.2.038250.t1(symbB.v1.2.038250.t1) v1.2.038250.t2(symbB.v1.2.038250.t2)
AAF: 
PIF: 
PSOJ: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:15841207]
  Authors
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV
  Title
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.
  Journal
J. Clin. Invest. 115 (2005) 1275-80.
Reference
2  [PMID:25531177]
  Authors
Beaupre BA, Hoag MR, Roman J, Forsterling FH, Moran GR
  Title
Metabolic function for human renalase: oxidation of isomeric forms of beta-NAD(P)H that are inhibitory to primary metabolism.
  Journal
Biochemistry. 54 (2015) 795-806.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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