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Entry
EC 1.6.5.8                  Enzyme                                 

Name
NADH:ubiquinone reductase (Na+-transporting);
Na+-translocating NADH-quinone reductase;
(Na+-NQR)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
NADH:ubiquinone oxidoreductase (Na+-translocating)
Reaction(IUBMB)
NADH + H+ + ubiquinone + n Na+in = NAD+ + ubiquinol + n Na+out [RN:R02163]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
ubiquinone [CPD:C00399];
Na+ [CPD:C01330]
Product
NAD+ [CPD:C00003];
ubiquinol [CPD:C00390];
Na+ [CPD:C01330]
Comment
An iron-sulfur flavoprotein, containing two covalently bound molecules of FMN, one noncovalently bound FAD, one riboflavin, and one [2Fe-2S] cluster.
History
EC 1.6.5.8 created 2011
Reference
1  [PMID:7805867]
  Authors
Beattie P, Tan K, Bourne RM, Leach D, Rich PR, Ward FB
  Title
Cloning and sequencing of four structural genes for the Na(+)-translocating NADH-ubiquinone oxidoreductase of Vibrio alginolyticus.
  Journal
FEBS. Lett. 356 (1994) 333-8.
Reference
2  [PMID:9490015]
  Authors
Nakayama Y, Hayashi M, Unemoto T
  Title
Identification of six subunits constituting Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus.
  Journal
FEBS. Lett. 422 (1998) 240-2.
Reference
3  [PMID:11401580]
  Authors
Bogachev AV, Bertsova YV, Barquera B, Verkhovsky MI
  Title
Sodium-dependent steps in the redox reactions of the Na+-motive NADH:quinone oxidoreductase from Vibrio harveyi.
  Journal
Biochemistry. 40 (2001) 7318-23.
Reference
4  [PMID:11888296]
  Authors
Barquera B, Hellwig P, Zhou W, Morgan JE, Hase CC, Gosink KK, Nilges M, Bruesehoff PJ, Roth A, Lancaster CR, Gennis RB
  Title
Purification and characterization of the recombinant Na(+)-translocating NADH:quinone oxidoreductase from Vibrio cholerae.
  Journal
Biochemistry. 41 (2002) 3781-9.
Reference
5  [PMID:15379571]
  Authors
Barquera B, Nilges MJ, Morgan JE, Ramirez-Silva L, Zhou W, Gennis RB
  Title
Mutagenesis study of the 2Fe-2S center and the FAD binding site of the Na(+)-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae.
  Journal
Biochemistry. 43 (2004) 12322-30.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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