KEGG   ENZYME: 1.6.5.9Help
Entry
EC 1.6.5.9                  Enzyme                                 

Name
NADH:ubiquinone reductase (non-electrogenic);
ubiquinone reductase;
coenzyme Q reductase;
dihydronicotinamide adenine dinucleotide-coenzyme Q reductase;
DPNH-coenzyme Q reductase;
DPNH-ubiquinone reductase;
NADH-coenzyme Q oxidoreductase;
NADH-coenzyme Q reductase;
NADH-CoQ oxidoreductase;
NADH-CoQ reductase;
NADH-ubiquinone reductase;
NADH-ubiquinone oxidoreductase;
reduced nicotinamide adenine dinucleotide-coenzyme Q reductase;
NADH-Q6 oxidoreductase;
electron transfer complex I;
NADH2 dehydrogenase (ubiquinone)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
NADH:ubiquinone oxidoreductase
Reaction(IUBMB)
NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
ubiquinone [CPD:C00399]
Product
NAD+ [CPD:C00003];
ubiquinol [CPD:C00390]
Comment
A flavoprotein (FAD). Occurs in mitochondria of yeast and plants, and in aerobic bacteria. Has low activity with NADPH.
History
EC 1.6.5.9 created 2011
Orthology
K17871  
NADH:ubiquinone reductase (non-electrogenic)
K17872  
NADH:ubiquinone reductase (non-electrogenic)
Genes
CIN: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G07180(NDA1) AT2G20800(NDB4) AT2G29990(NDA2) AT4G05020(NDB2) AT4G21490(NDB3) AT4G28220(NDB1) AT5G08740(NDC1)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0004s03410g(POPTRDRAFT_817755) POPTR_0004s03640g POPTR_0007s04850g(POPTRDRAFT_1082437) POPTR_0009s05180g(POPTRDRAFT_203252) POPTR_0013s14330g(POPTRDRAFT_571795) POPTR_0013s14340g(POPTRDRAFT_774032) POPTR_0013s14350g(POPTRDRAFT_571797) POPTR_234080
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0830100-01(Os01g0830100) Os05t0331200-01(Os05g0331200) Os06t0214900-01(Os06g0214900) Os07t0564500-01(Os07g0564500)
OBR: 
BDI: 
SBI: 
SORBI_02g036490(SORBIDRAFT_02g036490) SORBI_03g036480(SORBIDRAFT_03g036480) SORBI_03g038750(SORBIDRAFT_03g038750) SORBI_07g003070(SORBIDRAFT_07g003070) SORBI_10g007230(SORBIDRAFT_10g007230) SORBI_10g027690(SORBIDRAFT_10g027690)
ZMA: 
100274336(pco100812) 100275557(pco125920) 100279865 100282489(si618008g06(715)) 100382694
SITA: 
ATR: 
s00002p00068420(AMTR_s00002p00068420) s00003p00270010(AMTR_s00003p00270010) s00007p00124590(AMTR_s00007p00124590)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YDL085W(NDE2) YML120C(NDI1) YMR145C(NDE1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A03930(NCAS0A03930) NCAS_0B00240(NCAS0B00240) NCAS_0D01150(NCAS0D01150)
NDI: 
NDAI_0E00230(NDAI0E00230) NDAI_0E01660(NDAI0E01660) NDAI_0H03010(NDAI0H03010)
TPF: 
TPHA_0C04800(TPHA0C04800) TPHA_0G02580(TPHA0G02580)
TBL: 
TBLA_0B08910(TBLA0B08910) TBLA_0D03320(TBLA0D03320)
TDL: 
TDEL_0B00230(TDEL0B00230) TDEL_0G03120(TDEL0G03120)
KAF: 
KAFR_0A02890(KAFR0A02890) KAFR_0B05060(KAFR0B05060) KAFR_0F02920(KAFR0F02920)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.13136(NDE2) CaO19.339(NDE1) CaO19.5713(NDE2) CaO19.7972(NDE1)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_622164(AO090001000358)
ANG: 
ANI_1_610074(An08g04240)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
LBC: 
CCI: 
SCM: 
UMA: 
PGR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PTI: 
PIF: 
NGD: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1
  Authors
Moller, I.M, and Palmer, J.M.
  Title
Direct evidence for the presence of a rotenone-resistant NADH dehydrogenase on the inner surface of plant mitochondria.
  Journal
Physiol. Plant. 54 (1982) 267-274.
Reference
2  [PMID:3138118]
  Authors
de Vries S, Grivell LA
  Title
Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae.
  Journal
Eur. J. Biochem. 176 (1988) 377-84.
  Organism
Saccharomyces cerevisiae
  Sequence
[sce:YML120C]
Reference
3  [PMID:10381390]
  Authors
Kerscher SJ, Okun JG, Brandt U
  Title
A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica.
  Journal
J. Cell. Sci. 112 ( Pt 14) (1999) 2347-54.
  Organism
Yarrowia lipolytica
  Sequence
Reference
4  [PMID:15725055]
  Authors
Rasmusson AG, Soole KL, Elthon TE
  Title
Alternative NAD(P)H dehydrogenases of plant mitochondria.
  Journal
Annu. Rev. Plant. Biol. 55 (2004) 23-39.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-04-0

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