KEGG   ENZYME: 1.7.1.6Help
Entry
EC 1.7.1.6                  Enzyme                                 

Name
azobenzene reductase;
new coccine (NC)-reductase;
NC-reductase;
azo-dye reductase;
orange II azoreductase;
NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase;
orange I azoreductase;
azo reductase;
azoreductase;
nicotinamide adenine dinucleotide (phosphate) azoreductase;
NADPH2-dependent azoreductase;
dimethylaminobenzene reductase;
p-dimethylaminoazobenzene azoreductase;
dibromopropylaminophenylazobenzoic azoreductase;
N,N-dimethyl-4-phenylazoaniline azoreductase;
p-aminoazobenzene reductase;
methyl red azoreductase;
NADPH2:4-(dimethylamino)azobenzene oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase
Reaction(IUBMB)
N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ = 4-(dimethylamino)azobenzene + 2 NADPH + 2 H+ [RN:R05711]
Reaction(KEGG)
Substrate
N,N-dimethyl-1,4-phenylenediamine [CPD:C04203];
aniline [CPD:C00292];
NADP+ [CPD:C00006]
Product
4-(dimethylamino)azobenzene;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs in the reverse direction to that shown above. Other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B can also be reduced [2].
History
EC 1.7.1.6 created 1961 as EC 1.6.6.7, transferred 2002 to EC 1.7.1.6
Orthology
K03206  
azobenzene reductase
Genes
BSU: 
BSU09340(yhdA)
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BL02896(azr)
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BLi01002(yhdA)
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RBAU_0923(yhdA)
BAMN: 
BASU_0899(yhdA)
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BMP: 
NG74_00967(azr_1)
BAO: 
BAMF_1030(yhdA)
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LL3_01015(yhdA)
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 » show all
Taxonomy
Reference
1
  Authors
Mueller, G.C. and Miller, J.A.
  Title
The reductive cleavage of 4-dimethylaminoazobenzene by rat liver: the intracellular distribution of the enzyme system and its requirements for triphosphopyridine nucleotide.
  Journal
J. Biol. Chem. 180 (1949) 1125-1136.
Reference
2  [PMID:11134015]
  Authors
Suzuki Y, Yoda T, Ruhul A, Sugiura W.
  Title
Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil.
  Journal
J. Biol. Chem. 276 (2001) 9059-65.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9029-31-6

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