KEGG   ENZYME: 1.7.1.9Help
Entry
EC 1.7.1.9                  Enzyme                                 

Name
nitroquinoline-N-oxide reductase;
4-nitroquinoline 1-oxide reductase;
4NQO reductase;
NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase
Reaction(IUBMB)
4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+ [RN:R04228 R04229]
Reaction(KEGG)
Substrate
4-hydroxyaminoquinoline N-oxide [CPD:C04050];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
4-nitroquinoline N-oxide [CPD:C03474];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.7.1.9 created 1972 as EC 1.6.6.10, transferred 2002 to EC 1.7.1.9
Reference
1
  Authors
Toriyama, N.
  Title
[Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide].
  Journal
Nichidai Igaku Zasshi 24 (1965) 423-432.
Reference
2  [PMID:1370076]
  Authors
Stanley JS, York JL, Benson AM.
  Title
Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice.
  Journal
Cancer. Res. 52 (1992) 58-63.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-35-2

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