KEGG   ENZYME: 1.7.99.8Help
Entry
EC 1.7.99.8                 Enzyme                                 

Name
hydrazine oxidoreductase;
HAO (ambiguous;
cf. EC 1.7.3.4 hydroxylamine oxidase)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With other, unkown, acceptors
BRITE hierarchy
Sysname
hydrazine:acceptor oxidoreductase
Reaction(IUBMB)
hydrazine + acceptor = N2 + reduced acceptor [RN:R07174]
Reaction(KEGG)
Substrate
hydrazine [CPD:C05361];
acceptor [CPD:C00028]
Product
N2 [CPD:C00697];
reduced acceptor [CPD:C00030]
Comment
The enzyme is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria. The conversion of hydroxylamine by the enzyme from Brocadia anammoxidans results in the formation of NO and N2O [1]. Hydroxylamine is not a substrate for the enzyme from planctomycete KSU-1 [2].
History
EC 1.7.99.8 created 2003, modified 2010
Pathway
Nitrogen metabolism
Reference
1  [PMID:10820012]
  Authors
Schalk J, de Vries S, Kuenen JG, Jetten MS.
  Title
Involvement of a novel hydroxylamine oxidoreductase in anaerobic ammonium oxidation.
  Journal
Biochemistry. 39 (2000) 5405-12.
Reference
2  [PMID:11404106]
  Authors
Jetten MS, Wagner M, Fuerst J, van Loosdrecht M, Kuenen G, Strous M.
  Title
Microbiology and application of the anaerobic ammonium oxidation ('anammox') process.
  Journal
Curr. Opin. Biotechnol. 12 (2001) 283-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-43-8

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