KEGG   ENZYME: 1.8.1.13Help
Entry
EC 1.8.1.13                 Enzyme                                 

Name
bis-gamma-glutamylcystine reductase;
NADPH2:bis-gamma-glutamylcysteine oxidoreductase;
GSR
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
gamma-glutamylcysteine:NADP+ oxidoreductase
Reaction(IUBMB)
2 gamma-glutamylcysteine + NADP+ = bis-gamma-glutamylcystine + NADPH + H+ [RN:R02742]
Reaction(KEGG)
Substrate
gamma-glutamylcysteine [CPD:C00669];
NADP+ [CPD:C00006]
Product
bis-gamma-glutamylcystine [CPD:C03646];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Contains FAD. The enzyme, which is found only in halobacteria, maintains the concentration of gamma-glutamylcysteine, the major low molecular weight thiol in halobacteria. Not identical with EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.14 (CoA-disulfide reductase).
History
EC 1.8.1.13 created 1992 as EC 1.6.4.9, transferred 2002 to EC 1.8.1.13, modified 2013
Pathway
Glutathione metabolism
Reference
1  [PMID:3136140]
  Authors
Sundquist AR, Fahey RC.
  Title
The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes.
  Journal
J. Bacteriol. 170 (1988) 3459-67.
Reference
2  [PMID:2910862]
  Authors
Sundquist AR, Fahey RC.
  Title
The function of gamma-glutamylcysteine and bis-gamma-glutamylcystine reductase in Halobacterium halobium.
  Journal
J. Biol. Chem. 264 (1989) 719-25.
Reference
3  [PMID:23560638]
  Authors
Kim J, Copley SD
  Title
The orphan protein bis-gamma-glutamylcystine reductase joins the pyridine nucleotide disulfide reductase family.
  Journal
Biochemistry. 52 (2013) 2905-13.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
117056-54-9

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