KEGG   ENZYME: 1.8.1.14Help
Entry
EC 1.8.1.14                 Enzyme                                 

Name
CoA-disulfide reductase;
CoA-disulfide reductase (NADH2);
NADH2:CoA-disulfide oxidoreductase;
CoA:NAD+ oxidoreductase (misleading);
CoADR;
coenzyme A disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
CoA:NADP+ oxidoreductase
Reaction(IUBMB)
2 CoA + NADP+ = CoA-disulfide + NADPH + H+ [RN:R07175]
Reaction(KEGG)
Substrate
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
CoA-disulfide [CPD:C02015];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-gamma-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].
History
EC 1.8.1.14 created 1992 as EC 1.6.4.10, transferred 2002 to EC 1.8.1.14, modified 2005, modified 2013
Orthology
K08255  
CoA-disulfide reductase
Genes
SAU: 
SA0831(cdr)
SAV: 
SAV0970(cdr)
SAW: 
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SAM: 
MW0852(cdr)
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SH1979(cdr)
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 » show all
Taxonomy
Reference
1  [PMID:410791]
  Authors
Setlow B, Setlow P.
  Title
Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium.
  Journal
J. Bacteriol. 132 (1977) 444-52.
Reference
2  [PMID:9488707]
  Authors
delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE.
  Title
Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.
  Journal
J. Biol. Chem. 273 (1998) 5744-51.
  Sequence
Reference
3  [PMID:10052943]
  Authors
Luba J, Charrier V, Claiborne A.
  Title
Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides.
  Journal
Biochemistry. 38 (1999) 2725-37.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
206770-55-0

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