KEGG   ENZYME: 1.8.1.16Help
Entry
EC 1.8.1.16                 Enzyme                                 

Name
glutathione amide reductase;
GAR
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
glutathione amide:NAD+ oxidoreductase
Reaction(IUBMB)
2 glutathione amide + NAD+ = glutathione amide disulfide + NADH + H+ [RN:R09561]
Reaction(KEGG)
Substrate
glutathione amide [CPD:C19689];
NAD+ [CPD:C00003]
Product
glutathione amide disulfide [CPD:C19690];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
A dimeric flavoprotein (FAD). The enzyme restores glutathione amide disulfide, which is produced during the reduction of peroxide by EC 1.11.1.17 (glutathione amide-dependent peroxidase), back to glutathione amide (it catalyses the reaction in the opposite direction to that shown). The enzyme belongs to the family of flavoprotein disulfide oxidoreductases, but unlike other members of the family, which are specific for NADPH, it prefers NADH [1].
History
EC 1.8.1.16 created 2010
Reference
1  [PMID:11399772]
  Authors
Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ
  Title
Characterization of clutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide  redox cycling.
  Journal
J. Biol. Chem. 276 (2001) 20890-7.
Reference
2  [PMID:11807270]
  Authors
Vergauwen B, Van Petegem F, Remaut H, Pauwels F, Van Beeumen JJ
  Title
Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 58 (2002) 339-40.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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