KEGG   ENZYME: 1.8.1.18Help
Entry
EC 1.8.1.18                 Enzyme                                 

Name
NAD(P)H sulfur oxidoreductase (CoA-dependent);
NADPH NSR;
S0 reductase;
coenzyme A-dependent NADPH sulfur oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
hydrogen sulfide:NAD(P)+ oxidoreductase (CoA-dependent)
Reaction(IUBMB)
hydrogen sulfide + NAD(P)+ = sulfur + NAD(P)H + H+ [RN:R10419 R10438]
Reaction(KEGG)
Substrate
hydrogen sulfide [CPD:C00283];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
sulfur [CPD:C00087];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This FAD-dependent enzyme, characterized from the archaeon Pyrococcus furiosus, is responsible for NAD(P)H-linked sulfur reduction. The activity with NADH is about half of that with NADPH. The reaction is dependent on CoA, although the nature of this dependency is not well understood.
History
EC 1.8.1.18 created 2013
Genes
AFU: 
AFG: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
TAC: 
TVO: 
TVG0846070(TVG0846070)
PTO: 
FAC: 
PHO: 
PH0572(PH0572)
PAB: 
PAB0936(noxA-1)
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
IHO: 
IIS: 
IAG: 
HBU: 
PFM: 
PDL: 
SSO: 
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
PYW: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
TPE: 
THB: 
TCB: 
THF: 
ASC: 
CLG: 
 » show all
Taxonomy
Reference
1  [PMID:17449625]
  Authors
Schut GJ, Bridger SL, Adams MW
  Title
Insights into the metabolism of elemental sulfur by the hyperthermophilic archaeon Pyrococcus furiosus: characterization of a coenzyme A- dependent NAD(P)H sulfur oxidoreductase.
  Journal
J. Bacteriol. 189 (2007) 4431-41.
  Sequence
[pfu:PF1186]
Reference
2  [PMID:21965560]
  Authors
Bridger SL, Clarkson SM, Stirrett K, DeBarry MB, Lipscomb GL, Schut GJ, Westpheling J, Scott RA, Adams MW
  Title
Deletion strains reveal metabolic roles for key elemental sulfur-responsive proteins in Pyrococcus furiosus.
  Journal
J. Bacteriol. 193 (2011) 6498-504.
Reference
3  [PMID:15720393]
  Authors
Harris DR, Ward DE, Feasel JM, Lancaster KM, Murphy RD, Mallet TC, Crane EJ 3rd.
  Title
Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles.
  Journal
FEBS. J. 272 (2005) 1189-200.
  Sequence
[pho:PH0572]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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