Entry |
|
Name |
glutathione-disulfide reductase;
glutathione reductase;
glutathione reductase (NADPH);
NADPH-glutathione reductase;
GSH reductase;
GSSG reductase;
NADPH-GSSG reductase;
glutathione S-reductase;
NADPH:oxidized-glutathione oxidoreductase
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Class |
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
glutathione:NADP+ oxidoreductase
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Reaction(IUBMB) |
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ [RN: R00115]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.
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History |
EC 1.8.1.7 created 1961 as EC 1.6.4.2, modified 1989, transferred 2002 to EC 1.8.1.7
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Pathway |
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Orthology |
K00383 | glutathione reductase (NADPH) |
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Genes |
» show all
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Reference |
1 |
Authors |
Pai, E.F., Schirmer, R.H. and Schulz, G.E. |
Title |
Structural studies on crystalline glutathione reductase from human erythrocytes. |
Journal |
In: Singer, T.P. and Ondarza, R.N. (Eds.), Mechanisms of Oxidizing Enzymes, Mechanisms of Oxidizing Enzymes, New York, 1978, p. 17-22. |
Reference |
|
Authors |
Pigiet VP, Conley RR. |
Title |
Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography. |
Journal |
J. Biol. Chem. 252 (1977) 6367-72. |
Reference |
|
Authors |
RACKER E. |
Title |
Glutathione reductase from bakers' yeast and beef liver. |
Journal |
J. Biol. Chem. 217 (1955) 855-65. |
Reference |
|
Authors |
VAN HEYNINGEN R, PIRIE A. |
Title |
Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens. |
Journal |
Biochem. J. 53 (1953) 436-44. |
Reference |
|
Authors |
Worthington DJ, Rosemeyer MA. |
Title |
Glutathione reductase from human erythrocytes. Catalytic properties and aggregation. |
Journal |
Eur. J. Biochem. 67 (1976) 231-8. |
Reference |
|
Authors |
Bohme CC, Arscott LD, Becker K, Schirmer RH, Williams CH Jr. |
Title |
Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme. |
Journal |
J. Biol. Chem. 275 (2000) 37317-23. |
Reference |
|
Authors |
Libreros-Minotta CA, Pardo JP, Mendoza-Hernandez G, Rendon JL. |
Title |
Purification and characterization of glutathione reductase from Rhodospirillum rubrum. |
Journal |
Arch. Biochem. Biophys. 298 (1992) 247-53. |
Other DBs |
ExplorEnz - The Enzyme Database: | 1.8.1.7 |
ExPASy - ENZYME nomenclature database: | 1.8.1.7 |
BRENDA, the Enzyme Database: | 1.8.1.7 |
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