KEGG   ENZYME: 1.8.3.6Help
Entry
EC 1.8.3.6                  Enzyme                                 

Name
farnesylcysteine lyase;
FC lyase;
FCLY
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
S-(2E,6E)-farnesyl-L-cysteine oxidase
Reaction(IUBMB)
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2 [RN:R09562]
Reaction(KEGG)
Substrate
S-(2E,6E)-farnesyl-L-cysteine [CPD:C19691];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
(2E,6E)-farnesal [CPD:C03461];
L-cysteine [CPD:C00097];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). In contrast to mammalian EC 1.8.3.5 (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine.
History
EC 1.8.3.6 created 2011
Pathway
Terpenoid backbone biosynthesis
Orthology
K05906  
prenylcysteine oxidase / farnesylcysteine lyase
Genes
HSA: 
51449(PCYOX1)
PTR: 
470398(PCYOX1)
PPS: 
100971101(PCYOX1)
GGO: 
101138892(PCYOX1)
PON: 
100457284(PCYOX1)
MCC: 
MCF: 
MMU: 
66881(Pcyox1)
RNO: 
246302(Pcyox1)
CGE: 
100774789(Pcyox1)
HGL: 
TUP: 
CFA: 
481418(PCYOX1)
AML: 
FCA: 
BTA: 
100125835(PCYOX1)
BOM: 
PHD: 
CHX: 
SSC: 
100624596(PCYOX1)
CFR: 
102511924(PCYOX1)
ECB: 
MYB: 
102262695(PCYOX1)
MDO: 
100032803(PCYOX1)
SHR: 
OAA: 
GGA: 
426297(PCYOX1)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
ASN: 
102379956(PCYOX1)
PSS: 
ACS: 
XTR: 
549056(pcyox1)
DRE: 
550289(pcyox1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102366651(PCYOX1)
BFO: 
CIN: 
SPU: 
AME: 
412611(GB15892)
NVI: 
API: 
PHU: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
AQU: 
ATH: 
AT5G63910(FCLY)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0007s04570g(POPTRDRAFT_764062)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0692800-00(Os04g0692800)
BDI: 
SBI: 
SORBI_06g034170(SORBIDRAFT_06g034170)
SITA: 
SMO: 
PPP: 
CSL: 
CVR: 
CCP: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
ANG: 
ANI_1_1612144(An16g02960)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
CNE: 
CNB: 
CGI: 
LBC: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
TGO: 
PTM: 
PTI: 
TPS: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:19969520]
  Authors
Huizinga DH, Denton R, Koehler KG, Tomasello A, Wood L, Sen SE, Crowell DN
  Title
Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.
  Journal
Mol. Plant. 3 (2010) 143-55.
  Organism
Arabidopsis thaliana [GN:ath]
Reference
2  [PMID:17425716]
  Authors
Crowell DN, Huizinga DH, Deem AK, Trobaugh C, Denton R, Sen SE
  Title
Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine.
  Journal
Plant. J. 50 (2007) 839-47.
  Organism
Arabidopsis thaliana [GN:ath]
  Sequence
[ath:AT5G63910]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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