KEGG   ENZYME: 1.8.4.13Help
Entry
EC 1.8.4.13                 Enzyme                                 

Name
L-methionine (S)-S-oxide reductase;
fSMsr;
methyl sulfoxide reductase I and II;
acetylmethionine sulfoxide reductase;
methionine sulfoxide reductase;
L-methionine:oxidized-thioredoxin S-oxidoreductase;
methionine-S-oxide reductase;
free-methionine (S)-S-oxide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
L-methionine:thioredoxin-disulfide S-oxidoreductase
Reaction(IUBMB)
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin [RN:R07606]
Reaction(KEGG)
R07606;
(other) R02025
Show
Substrate
L-methionine [CPD:C00073];
thioredoxin disulfide [CPD:C00343];
H2O [CPD:C00001]
Product
L-methionine (S)-S-oxide [CPD:C15999];
thioredoxin [CPD:C00342]
Comment
Requires NADPH [2]. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC 1.8.4.14, L-methionine (R)-S-oxide reductase].
History
EC 1.8.4.13 created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.13
Pathway
Cysteine and methionine metabolism
Reference
1
  Authors
Black, S., Harte, E.M., Hudson, B. and Wartofsky, L.
  Title
A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides.
  Journal
J. Biol. Chem. 235 (1960) 2910-2916.
Reference
2  [PMID:37234]
  Authors
Ejiri SI, Weissbach H, Brot N.
  Title
Reduction of methionine sulfoxide to methionine by Escherichia coli.
  Journal
J. Bacteriol. 139 (1979) 161-4.
  Organism
Escherichia coli
Reference
3  [PMID:6999943]
  Authors
Ejiri SI, Weissbach H, Brot N.
  Title
The purification of methionine sulfoxide reductase from Escherichia coli.
  Journal
Anal. Biochem. 102 (1980) 393-8.
  Organism
Escherichia coli
Reference
4  [PMID:15680228]
  Authors
Weissbach H, Resnick L, Brot N.
  Title
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.
  Journal
Biochim. Biophys. Acta. 1703 (2005) 203-12.
  Organism
Escherichia coli
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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