KEGG   ENZYME: 1.8.4.14Help
Entry
EC 1.8.4.14                 Enzyme                                 

Name
L-methionine (R)-S-oxide reductase;
fRMsr;
FRMsr;
free met-R-(o) reductase;
free-methionine (R)-S-oxide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming]
Reaction(IUBMB)
L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin [RN:R07608]
Reaction(KEGG)
R07608;
(other) R02025
Show
Substrate
L-methionine [CPD:C00073];
thioredoxin disulfide [CPD:C00343];
H2O [CPD:C00001]
Product
L-methionine (R)-S-oxide [CPD:C15998];
thioredoxin [CPD:C00342]
Comment
Requires NADPH. Unlike EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC 1.8.4.13, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.
History
EC 1.8.4.14 created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.14
Pathway
Cysteine and methionine metabolism
Orthology
K08968  
L-methionine (R)-S-oxide reductase
Genes
SCE: 
YKL069W(YKG9)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0H03260(NCAS0H03260)
NDI: 
NDAI_0C00400(NDAI0C00400)
TPF: 
TPHA_0C02490(TPHA0C02490)
TBL: 
TBLA_0A10200(TBLA0A10200)
TDL: 
TDEL_0B07070(TDEL0B07070)
KAF: 
KAFR_0C04110(KAFR0C04110)
DHA: 
PIC: 
PGU: 
CAL: 
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
TRE: 
VAL: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_766114(AO090701000421)
ANG: 
ANI_1_636034(An03g05080)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
AJE: 
PNO: 
ZTR: 
CNE: 
CNB: 
CGI: 
SCM: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:12504094]
  Authors
Etienne F, Spector D, Brot N, Weissbach H.
  Title
A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide.
  Journal
Biochem. Biophys. Res. Commun. 300 (2003) 378-82.
  Organism
Escherichia coli
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
945954-12-1

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