KEGG   ENZYME: 1.8.4.2Help
Entry
EC 1.8.4.2                  Enzyme                                 

Name
protein-disulfide reductase (glutathione);
glutathione-insulin transhydrogenase;
insulin reductase;
reductase, protein disulfide (glutathione);
protein disulfide transhydrogenase;
glutathione-protein disulfide oxidoreductase;
protein disulfide reductase (glutathione);
GSH-insulin transhydrogenase;
protein-disulfide interchange enzyme;
protein-disulfide isomerase/oxidoreductase;
thiol:protein-disulfide oxidoreductase;
thiol-protein disulphide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
glutathione:protein-disulfide oxidoreductase
Reaction(IUBMB)
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol [RN:R03915]
Reaction(KEGG)
R03915;
(other) R02824
Show
Substrate
glutathione [CPD:C00051];
protein disulfide [CPD:C02582]
Product
glutathione disulfide [CPD:C00127];
protein dithiol [CPD:C02315]
Comment
Reduces insulin and some other proteins.
History
EC 1.8.4.2 created 1965
Pathway
Glutathione metabolism
Orthology
K05360  
protein-disulfide reductase (glutathione)
Genes
HSA: 
51060(TXNDC12)
PTR: 
100610643(TXNDC12)
PPS: 
100996005(TXNDC12)
GGO: 
101134035(TXNDC12)
PON: 
100451283(TXNDC12)
NLE: 
105737527(TXNDC12)
MCC: 
712891(TXNDC12)
MCF: 
102121050(TXNDC12)
CSAB: 
103224818(TXNDC12)
RRO: 
104667843(TXNDC12)
CJC: 
100400300(TXNDC12)
SBQ: 
101039421(TXNDC12)
MMU: 
66073(Txndc12)
RNO: 
298370(Txndc12)
CGE: 
100753389(Txndc12)
NGI: 
103730255(Txndc12)
HGL: 
101714855(Txndc12)
OCU: 
103350186(TXNDC12)
TUP: 
102497800(TXNDC12)
CFA: 
609843(TXNDC12)
AML: 
100481735(TXNDC12)
UMR: 
103670719(TXNDC12)
FCA: 
101089631(TXNDC12)
PTG: 
102956818(TXNDC12)
BTA: 
506991(TXNDC12)
BOM: 
102276264(TXNDC12)
PHD: 
CHX: 
102189539(TXNDC12)
OAS: 
101113445(TXNDC12)
SSC: 
100517534(TXNDC12)
CFR: 
102511212(TXNDC12)
BACU: 
103015400(TXNDC12)
LVE: 
103070023(TXNDC12)
ECB: 
100062254(TXNDC12)
MYB: 
102252702(TXNDC12)
MYD: 
102760942(TXNDC12)
PALE: 
102881310(TXNDC12)
LAV: 
100655830(TXNDC12)
MDO: 
103095270(TXNDC12)
SHR: 
105750619(TXNDC12)
OAA: 
100078583(TXNDC12)
GGA: 
772208(TXNDC12)
MGP: 
100541059(TXNDC12)
CJO: 
107317647(TXNDC12)
APLA: 
101799624(TXNDC12)
TGU: 
100225061(TXNDC12)
GFR: 
102041968(TXNDC12)
FAB: 
101807031(TXNDC12)
PHI: 
102103484(TXNDC12)
CCW: 
104695524(TXNDC12)
FPG: 
101917720(TXNDC12)
FCH: 
102059863(TXNDC12)
CLV: 
102085011(TXNDC12)
AAM: 
106491077(TXNDC12)
ASN: 
102381430(TXNDC12)
AMJ: 
102573479(TXNDC12)
PSS: 
102446057(TXNDC12)
CMY: 
102942750(TXNDC12)
ACS: 
100562080(txndc12)
PBI: 
103066536(TXNDC12)
GJA: 
107111061(TXNDC12)
XLA: 
380448(tlp19)
XTR: 
100379783(txndc12)
DRE: 
324900(txndc12)
TRU: 
101067813(txndc12)
TNG: 
MZE: 
101479452(txndc12)
OLA: 
101170372(txndc12)
XMA: 
102228365(txndc12)
SASA: 
100286440(txndc12)
LCM: 
102357648(TXNDC12)
CMK: 
103172677(txndc12)
BFO: 
CIN: 
SPU: 
SKO: 
SOC: 
AEC: 
HST: 
BMOR: 
DPL: 
PXY: 
PHU: 
BMY: 
LOA: 
TSP: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
TAD: 
CRE: 
CSL: 
MBR: 
SRE: 
EIV: 
ACAN: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:14031343]
  Authors
KATZEN HM, TIETZE F, STETTEN D Jr.
  Title
Further studies on the properties of hepatic glutathione-insulin transhydro-genase.
  Journal
J. Biol. Chem. 238 (1963) 1006-11.
Reference
2
  Authors
Kohnert, K.-D., Hahn, H.-J., Zuhlke, H., Schmidt, S. and Fiedler, H.
  Title
Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro.
  Journal
Biochim. Biophys. Acta 338 (1974) 68-77.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9082-53-5

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